Predictive Biomarkers of Sensitivity to the Aurora and Angiogenic Kinase Inhibitor ENMD-2076 in Preclinical Breast Cancer Models

PURPOSE: The Aurora kinases are a family of conserved serine-threonine kinases with key roles in mitotic cell division. As with other promising anti-cancer targets, patient selection strategies to identify a responsive subtype will likely be required for successful clinical development of Aurora kin...

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Main Authors: Diamond, Jennifer R., Eckhardt, S. Gail, Tan, Aik Choon, Newton, Timothy P., Selby, Heather M., Brunkow, Kelsey L., Kachaeva, Maria I., Varella-Garcia, Marileila, Pitts, Todd M., Bray, Mark R., Fletcher, Graham C., Tentler, John J.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2012
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537923/
https://ncbi.nlm.nih.gov/pubmed/23136197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-1611
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