Efficacy and Molecular Mechanisms of Differentiated Response to the Aurora and Angiogenic Kinase Inhibitor ENMD-2076 in Preclinical Models of p53-Mutated Triple-Negative Breast Cancer

PURPOSE: Triple-negative breast cancer (TNBC) is a subtype associated with poor prognosis and for which there are limited therapeutic options. The purpose of this study was to evaluate the efficacy of ENMD-2076 in p53-mutated TNBC patient-derived xenograft (PDX) models and describe patterns of termi...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Ionkina, Anastasia A., Tentler, John J., Kim, Jihye, Capasso, Anna, Pitts, Todd M., Ryall, Karen A., Howison, Rebekah R., Kabos, Peter, Sartorius, Carol A., Tan, Aik Choon, Eckhardt, S. Gail, Diamond, Jennifer R.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5430301/
https://ncbi.nlm.nih.gov/pubmed/28555173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2017.00094
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