Rational Combination of a MEK Inhibitor, Selumetinib, and the Wnt/Calcium Pathway Modulator, Cyclosporin A, in Preclinical Models of Colorectal Cancer

PURPOSE: The MAPK pathway is a crucial regulator of cell proliferation, survival, and resistance to apoptosis. MEK inhibitors are being explored as a treatment option for patients with KRAS mutant colorectal cancer (CRC) who are not candidates for EGFR-directed therapies. Initial clinical results of...

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Autori principali: Spreafico, Anna, Tentler, John J., Pitts, Todd M., Tan, Aik Choon, Gregory, Mark A., Arcaroli, John J., Klauck, Peter J., McManus, Martine C., Hansen, Ryan J., Kim, Jihye, Micel, Lindsey N., Selby, Heather M., Newton, Timothy P., McPhillips, Kelly, Gustafson, Daniel L., DeGregori, James V., Messersmith, Wells A., Winn, Robert A., Eckhardt, S. Gail
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3905307/
https://ncbi.nlm.nih.gov/pubmed/23757356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-3140
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