Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349

[Image: see text] Aberrant activation of the PI3K-Akt-mTOR signaling pathway has been observed in human tumors and tumor cell lines, indicating that these protein kinases may be attractive therapeutic targets for treating cancer. Optimization of advanced lead 1 culminated in the discovery of clinica...

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Bibliografiske detaljer
Main Authors: Pei, Zhonghua, Blackwood, Elizabeth, Liu, Lichuan, Malek, Shiva, Belvin, Marcia, Koehler, Michael F. T., Ortwine, Daniel F., Chen, Huifen, Cohen, Frederick, Kenny, Jane R., Bergeron, Philippe, Lau, Kevin, Ly, Cuong, Zhao, Xianrui, Estrada, Anthony A., Truong, Tom, Epler, Jennifer A., Nonomiya, Jim, Trinh, Lan, Sideris, Steve, Lesnick, John, Bao, Linda, Vijapurkar, Ulka, Mukadam, Sophie, Tay, Suzanne, Deshmukh, Gauri, Chen, Yung-Hsiang, Ding, Xiao, Friedman, Lori S., Lyssikatos, Joseph P.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2012
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027466/
https://ncbi.nlm.nih.gov/pubmed/24900569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml3003132
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