Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349

[Image: see text] Aberrant activation of the PI3K-Akt-mTOR signaling pathway has been observed in human tumors and tumor cell lines, indicating that these protein kinases may be attractive therapeutic targets for treating cancer. Optimization of advanced lead 1 culminated in the discovery of clinica...

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Main Authors: Pei, Zhonghua, Blackwood, Elizabeth, Liu, Lichuan, Malek, Shiva, Belvin, Marcia, Koehler, Michael F. T., Ortwine, Daniel F., Chen, Huifen, Cohen, Frederick, Kenny, Jane R., Bergeron, Philippe, Lau, Kevin, Ly, Cuong, Zhao, Xianrui, Estrada, Anthony A., Truong, Tom, Epler, Jennifer A., Nonomiya, Jim, Trinh, Lan, Sideris, Steve, Lesnick, John, Bao, Linda, Vijapurkar, Ulka, Mukadam, Sophie, Tay, Suzanne, Deshmukh, Gauri, Chen, Yung-Hsiang, Ding, Xiao, Friedman, Lori S., Lyssikatos, Joseph P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027466/
https://ncbi.nlm.nih.gov/pubmed/24900569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml3003132
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