Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR

[Image: see text] Inhibition of phosphoinositide 3-kinase (PI3K) signaling is an appealing approach to treat brain tumors, especially glioblastoma multiforme (GBM). We previously disclosed our successful approach to prospectively design potent and blood–brain barrier (BBB) penetrating PI3K inhibitor...

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書誌詳細
出版年:ACS Med Chem Lett
主要な著者: Heffron, Timothy P., Ndubaku, Chudi O., Salphati, Laurent, Alicke, Bruno, Cheong, Jonathan, Drobnick, Joy, Edgar, Kyle, Gould, Stephen E., Lee, Leslie B., Lesnick, John D., Lewis, Cristina, Nonomiya, Jim, Pang, Jodie, Plise, Emile G., Sideris, Steve, Wallin, Jeffrey, Wang, Lan, Zhang, Xiaolin, Olivero, Alan G.
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2016
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834666/
https://ncbi.nlm.nih.gov/pubmed/27096040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00005
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