Multi-parametric MR-PET imaging predicts pharmacokinetics and clinical response to GDC-0084 in patients with recurrent high-grade glioma

PURPOSE: GDC-0084 is an oral, brain-penetrant small molecule inhibitor of phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR). Since these two targets alter tumor vascularity and metabolism, respectively, we hypothesized multi-parametric MR-PET could be used to quantify the res...

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Pubblicato in:Clin Cancer Res
Autori principali: Ellingson, Benjamin M., Yao, Jingwen, Raymond, Catalina, Nathanson, David A., Chakhoyan, Ararat, Simpson, Jeremy, Garner, James, Olivero, Alan, Mueller, Lars, Rodon, Jordi, Gerstner, Elizabeth R., Cloughesy, Timothy F., Wen, Patrick Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8204664/
https://ncbi.nlm.nih.gov/pubmed/32269051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-3817
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