NIMG-34. MULTI-PARAMETRIC MR-PET IMAGING PREDICTS PHARMACOKINETICS AND CLINICAL RESPONSE TO GDC-0084 IN HUMAN RECURRENT HIGH-GRADE GLIOMA

Alterations in the PI3K pathway are found in the majority of malignant gliomas, but lack of efficacy has caused investigators to question the viability of this target, particularly due to lack of brain penetration. GDC-0084 was specifically optimized to penetrate the brain, targeting both PI3K and m...

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Bibliographische Detailangaben
Veröffentlicht in:Neuro Oncol
Hauptverfasser: Ellingson, Benjamin, Yao, Jingwen, Raymond, Catalina, Nathanson, David, Simpson, Jeremy, Garner, James, Olivero, Alan, Mueller, Lars, Rodon, Jordi, Gerstner, Elizabeth, Cloughesy, Timothy, Wen, Patrick
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
Neuro-Imaging
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847015/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.704
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