Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR

[Image: see text] Inhibition of phosphoinositide 3-kinase (PI3K) signaling is an appealing approach to treat brain tumors, especially glioblastoma multiforme (GBM). We previously disclosed our successful approach to prospectively design potent and blood–brain barrier (BBB) penetrating PI3K inhibitor...

Full description

Saved in:
Bibliographic Details
Published in:ACS Med Chem Lett
Main Authors: Heffron, Timothy P., Ndubaku, Chudi O., Salphati, Laurent, Alicke, Bruno, Cheong, Jonathan, Drobnick, Joy, Edgar, Kyle, Gould, Stephen E., Lee, Leslie B., Lesnick, John D., Lewis, Cristina, Nonomiya, Jim, Pang, Jodie, Plise, Emile G., Sideris, Steve, Wallin, Jeffrey, Wang, Lan, Zhang, Xiaolin, Olivero, Alan G.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2016
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834666/
https://ncbi.nlm.nih.gov/pubmed/27096040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00005
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items