Challenges of developing small-molecule kinase inhibitors for brain tumors and the need for emphasis on free drug levels

由 Heffron, Timothy P
發表在 Neuro Oncol (2018)

Ladder Polyether Synthesis via Epoxide-Opening Cascades Directed by a Disappearing Trimethylsilyl Group

由 Heffron, Timothy P., Simpson, Graham L., Merino, Estibaliz, Jamison, Timothy F.
出版 2010

CNS Anticancer Drug Discovery and Development: 2016 conference insights

由 Levin, Victor A, Abrey, Lauren E, Heffron, Timothy P, Tonge, Peter J, Dar, Arvin C, Weiss, William A, Gallo, James M
發表在 CNS Oncol (2017)

Non-Covalent Wild-Type-Sparing Inhibitors of EGFR T790M

由 Lee, Ho-June, Schaefer, Gabriele, Heffron, Timothy P., Shao, Lily, Ye, Xiaofen, Sideris, Steve, Malek, Shiva, Chan, Emily, Merchant, Mark, La, Hank, Ubhayakar, Savita, Yauch, Robert L., Pirazzoli, Valentina, Politi, Katerina, Settleman, Jeff
出版 2012

Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR

由 Heffron, Timothy P., Ndubaku, Chudi O., Salphati, Laurent, Alicke, Bruno, Cheong, Jonathan, Drobnick, Joy, Edgar, Kyle, Gould, Stephen E., Lee, Leslie B., Lesnick, John D., Lewis, Cristina, Nonomiya, Jim, Pang, Jodie, Plise, Emile G., Sideris, Steve, Wallin, Jeffrey, Wang, Lan, Zhang, Xiaolin, Olivero, Alan G.
發表在 ACS Med Chem Lett (2016)

Pyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR

由 Bryan, Marian C., Burdick, Daniel J., Chan, Bryan K., Chen, Yuan, Clausen, Saundra, Dotson, Jennafer, Eigenbrot, Charles, Elliott, Richard, Hanan, Emily J., Heald, Robert, Jackson, Philip, La, Hank, Lainchbury, Michael, Malek, Shiva, Mann, Sam E., Purkey, Hans E., Schaefer, Gabriele, Schmidt, Stephen, Seward, Eileen, Sideris, Steve, Wang, Shumei, Yen, Ivana, Yu, Christine, Heffron, Timothy P.
發表在 ACS Med Chem Lett (2015)

CNS Anticancer Drug Discovery and Development Conference White Paper

由 Levin, Victor A., Tonge, Peter J., Gallo, James M., Birtwistle, Marc R., Dar, Arvin C., Iavarone, Antonio, Paddison, Patrick J., Heffron, Timothy P., Elmquist, William F., Lachowicz, Jean E., Johnson, Ted W., White, Forest M., Sul, Joohee, Smith, Quentin R., Shen, Wang, Sarkaria, Jann N., Samala, Ramakrishna, Wen, Patrick Y., Berry, Donald A., Petter, Russell C.
發表在 Neuro Oncol (2015)

Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation

由 Hanan, Emily J., Eigenbrot, Charles, Bryan, Marian C., Burdick, Daniel J., Chan, Bryan K., Chen, Yuan, Dotson, Jennafer, Heald, Robert A., Jackson, Philip S., La, Hank, Lainchbury, Michael D., Malek, Shiva, Purkey, Hans E., Schaefer, Gabriele, Schmidt, Stephen, Seward, Eileen M., Sideris, Steve, Tam, Christine, Wang, Shumei, Yeap, Siew Kuen, Yen, Ivana, Yin, Jianping, Yu, Christine, Zilberleyb, Inna, Heffron, Timothy P.
發表在 J Med Chem (2014)