The ErbB4 extracellular region retains a tethered-like conformation in the absence of the tether

অনুযায়ী Liu, Ping, Bouyain, Samuel, Eigenbrot, Charles, Leahy, Daniel J
প্রকাশিত 2012

Structural basis for high-affinity HER2 receptor binding by an engineered protein

অনুযায়ী Eigenbrot, Charles, Ultsch, Mark, Dubnovitsky, Anatoly, Abrahmsén, Lars, Härd, Torleif
প্রকাশিত 2010

Structure of the pseudokinase–kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition

অনুযায়ী Lupardus, Patrick J., Ultsch, Mark, Wallweber, Heidi, Bir Kohli, Pawan, Johnson, Adam R., Eigenbrot, Charles
প্রকাশিত 2014

Disulfide locked variants of factor VIIa with a restricted β-strand conformation have enhanced enzymatic activity

অনুযায়ী Maun, Henry R., Eigenbrot, Charles, Raab, Helga, Arnott, David, Phu, Lilian, Bullens, Sherron, Lazarus, Robert A.
প্রকাশিত 2005

Structural basis of the broadly neutralizing anti-interferon-α antibody rontalizumab

অনুযায়ী Maurer, Brigitte, Bosanac, Ivan, Shia, Steven, Kwong, Mandy, Corpuz, Racquel, Vandlen, Richard, Schmidt, Kerstin, Eigenbrot, Charles
প্রকাশিত Protein Sci (2015)

Dual functionality of β-tryptase protomers as both proteases and cofactors in the active tetramer

অনুযায়ী Maun, Henry R., Liu, Peter S., Franke, Yvonne, Eigenbrot, Charles, Forrest, William F., Schwartz, Lawrence B., Lazarus, Robert A.
প্রকাশিত J Biol Chem (2018)

Structural insight into distinct mechanisms of protease inhibition by antibodies

অনুযায়ী Wu, Yan, Eigenbrot, Charles, Liang, Wei-Ching, Stawicki, Scott, Shia, Steven, Fan, Bin, Ganesan, Rajkumar, Lipari, Michael T., Kirchhofer, Daniel
প্রকাশিত 2007

Generation of a high-fidelity antibody against nerve growth factor using library scanning mutagenesis and validation with structures of the initial and optimized Fab-antigen comple...

অনুযায়ী La Porte, Sherry L, Eigenbrot, Charles, Ultsch, Mark, Ho, Wei-Hsien, Foletti, Davide, Forgie, Alison, Lindquist, Kevin C, Shelton, David L, Pons, Jaume
প্রকাশিত 2014

Endocytosis and Sorting of ErbB2 and the Site of Action of Cancer Therapeutics Trastuzumab and Geldanamycin

অনুযায়ী Austin, Cary D., De Mazière, Ann M., Pisacane, Paul I., van Dijk, Suzanne M., Eigenbrot, Charles, Sliwkowski, Mark X., Klumperman, Judith, Scheller, Richard H.
প্রকাশিত 2004

Utilizing the activation mechanism of serine proteases to engineer hepatocyte growth factor into a Met antagonist

অনুযায়ী Kirchhofer, Daniel, Lipari, Michael T., Santell, Lydia, Billeci, Karen L., Maun, Henry R., Sandoval, Wendy N., Moran, Paul, Ridgway, John, Eigenbrot, Charles, Lazarus, Robert A.
প্রকাশিত 2007

Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif

অনুযায়ী Ultsch, Mark, Holliday, Michael J., Gerhardy, Stefan, Moran, Paul, Scales, Suzie J., Gupta, Nidhi, Oltrabella, Francesca, Chiu, Cecilia, Fairbrother, Wayne, Eigenbrot, Charles, Kirchhofer, Daniel
প্রকাশিত Commun Biol (2021)

Identification of a Small Peptide That Inhibits PCSK9 Protein Binding to the Low Density Lipoprotein Receptor

অনুযায়ী Zhang, Yingnan, Eigenbrot, Charles, Zhou, Lijuan, Shia, Steven, Li, Wei, Quan, Clifford, Tom, Jeffrey, Moran, Paul, Di Lello, Paola, Skelton, Nicholas J., Kong-Beltran, Monica, Peterson, Andrew, Kirchhofer, Daniel
প্রকাশিত 2014

Framework selection can influence pharmacokinetics of a humanized therapeutic antibody through differences in molecule charge

অনুযায়ী Li, Bing, Tesar, Devin, Boswell, C Andrew, Cahaya, Hendry S, Wong, Anne, Zhang, Jianhuan, Meng, Y Gloria, Eigenbrot, Charles, Pantua, Homer, Diao, Jinyu, Kapadia, Sharookh B, Deng, Rong, Kelley, Robert F
প্রকাশিত MAbs (2014)

Structure of Crenezumab Complex with Aβ Shows Loss of β-Hairpin

অনুযায়ী Ultsch, Mark, Li, Bing, Maurer, Till, Mathieu, Mary, Adolfsson, Oskar, Muhs, Andreas, Pfeifer, Andrea, Pihlgren, Maria, Bainbridge, Travis W., Reichelt, Mike, Ernst, James A., Eigenbrot, Charles, Fuh, Germaine, Atwal, Jasvinder K., Watts, Ryan J., Wang, Weiru
প্রকাশিত Sci Rep (2016)

Generation and characterization of a unique reagent that recognizes a panel of recombinant human monoclonal antibody therapeutics in the presence of endogenous human IgG

অনুযায়ী Wang, Xiangdan, Quarmby, Valerie, Ng, Carl, Chuntharapai, Anan, Shek, Theresa, Eigenbrot, Charles, Kelley, Robert F., Shia, Steven, McCutcheon, Krista M, Lowe, John, Leddy, Cecilia, Coachman, Kyle, Cain, Gary, Chu, Felix, Hotzel, Isidro, Maia, Mauricio, Wakshull, Eric, Yang, Jihong
প্রকাশিত 2013

Bivalent antibody pliers inhibit β-tryptase by an allosteric mechanism dependent on the IgG hinge

অনুযায়ী Maun, Henry R., Vij, Rajesh, Walters, Benjamin T., Morando, Ashley, Jackman, Janet K., Wu, Ping, Estevez, Alberto, Chen, Xiaocheng, Franke, Yvonne, Lipari, Michael T., Dennis, Mark S., Kirchhofer, Daniel, Ciferri, Claudio, Loyet, Kelly M., Yi, Tangsheng, Eigenbrot, Charles, Lazarus, Robert A., Koerber, James T.
প্রকাশিত Nat Commun (2020)

Stereochemical Differences in Fluorocyclopropyl Amides Enable Tuning of Btk Inhibition and Off-Target Activity

অনুযায়ী Crawford, James J., Lee, Wendy, Johnson, Adam R., Delatorre, Kelly J., Chen, Jacob, Eigenbrot, Charles, Heidmann, Julia, Kakiuchi-Kiyota, Satoko, Katewa, Arna, Kiefer, James R., Liu, Lichuan, Lubach, Joseph W., Misner, Dinah, Purkey, Hans, Reif, Karin, Vogt, Jennifer, Wong, Harvey, Yu, Christine, Young, Wendy B.
প্রকাশিত ACS Med Chem Lett (2020)

Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a Pyridopyridazinone pan-RAF Kinase Inhibitor

অনুযায়ী Huestis, Malcolm P., Durk, Matthew R., Eigenbrot, Charles, Gibbons, Paul, Hunsaker, Thomas L., La, Hank, Leung, Dennis H., Liu, Wendy, Malek, Shiva, Merchant, Mark, Moffat, John G., Muli, Christine S., Orr, Christine J., Parr, Brendan T., Shanahan, Frances, Sneeringer, Christopher J., Wang, Weiru, Yen, Ivana, Yin, Jianping, Rudolph, Joachim, Siu, Michael
প্রকাশিত ACS Med Chem Lett (2021)

Pyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR

অনুযায়ী Bryan, Marian C., Burdick, Daniel J., Chan, Bryan K., Chen, Yuan, Clausen, Saundra, Dotson, Jennafer, Eigenbrot, Charles, Elliott, Richard, Hanan, Emily J., Heald, Robert, Jackson, Philip, La, Hank, Lainchbury, Michael, Malek, Shiva, Mann, Sam E., Purkey, Hans E., Schaefer, Gabriele, Schmidt, Stephen, Seward, Eileen, Sideris, Steve, Wang, Shumei, Yen, Ivana, Yu, Christine, Heffron, Timothy P.
প্রকাশিত ACS Med Chem Lett (2015)

Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity

অনুযায়ী Dendrou, Calliope A., Cortes, Adrian, Shipman, Lydia, Evans, Hayley G., Attfield, Kathrine E., Jostins, Luke, Barber, Thomas, Kaur, Gurman, Kuttikkatte, Subita Balaram, Leach, Oliver A., Desel, Christiane, Faergeman, Soren L., Cheeseman, Jane, Neville, Matt J., Sawcer, Stephen, Compston, Alastair, Johnson, Adam R., Everett, Christine, Bell, John I., Karpe, Fredrik, Ultsch, Mark, Eigenbrot, Charles, McVean, Gil, Fugger, Lars
প্রকাশিত Sci Transl Med (2016)