Endocytosis and Sorting of ErbB2 and the Site of Action of Cancer Therapeutics Trastuzumab and Geldanamycin

ErbB2 is a transmembrane tyrosine kinase whose surface overexpression is linked to tumorigenesis and poor prognosis in breast cancer patients. Two models have emerged that account for the high surface distribution of ErbB2. In one model, the surface pool is dynamic and governed by a balance between...

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Main Authors: Austin, Cary D., De Mazière, Ann M., Pisacane, Paul I., van Dijk, Suzanne M., Eigenbrot, Charles, Sliwkowski, Mark X., Klumperman, Judith, Scheller, Richard H.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Cell Biology 2004
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC532009/
https://ncbi.nlm.nih.gov/pubmed/15385631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E04-07-0591
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