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Clathrin-Independent Endocytosis of ErbB2 in Geldanamycin-Treated Human Breast Cancer Cells
The EGF receptor family member ErbB2 in is commonly overexpressed in human breast cancer cells and correlates with poor prognosis. Geldanamycin (GA) induces ErbB2 ubiquitination, intracellular accumulation, and degradation. Whether GA stimulates ErbB2 internalization is controversial. We found that...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2707784/ https://ncbi.nlm.nih.gov/pubmed/18765569 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.020404 |
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