Epidermal growth factor–stimulated Akt phosphorylation requires clathrin or ErbB2 but not receptor endocytosis

Epidermal growth factor (EGF) binding to its receptor (EGFR) activates several signaling intermediates, including Akt, leading to control of cell survival and metabolism. Concomitantly, ligand-bound EGFR is incorporated into clathrin-coated pits—membrane structures containing clathrin and other prot...

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Bibliografiske detaljer
Udgivet i:Mol Biol Cell
Main Authors: Garay, Camilo, Judge, Gurjeet, Lucarelli, Stefanie, Bautista, Stephen, Pandey, Rohan, Singh, Tanveer, Antonescu, Costin N.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591694/
https://ncbi.nlm.nih.gov/pubmed/26246598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E14-09-1412
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