Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity

Thousands of genetic variants have been identified that contribute to the development of complex diseases, but determining how to fully elucidate their biological consequences for translation into clinical benefit is challenging. Conflicting evidence regarding the functional impact of genetic varian...

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Publicado en:Sci Transl Med
Main Authors: Dendrou, Calliope A., Cortes, Adrian, Shipman, Lydia, Evans, Hayley G., Attfield, Kathrine E., Jostins, Luke, Barber, Thomas, Kaur, Gurman, Kuttikkatte, Subita Balaram, Leach, Oliver A., Desel, Christiane, Faergeman, Soren L., Cheeseman, Jane, Neville, Matt J., Sawcer, Stephen, Compston, Alastair, Johnson, Adam R., Everett, Christine, Bell, John I., Karpe, Fredrik, Ultsch, Mark, Eigenbrot, Charles, McVean, Gil, Fugger, Lars
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737835/
https://ncbi.nlm.nih.gov/pubmed/27807284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aag1974
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