Structural basis of IFNα receptor recognition by TYK2

Por Wallweber, Heidi J.A., Tam, Christine, Franke, Yvonne, Starovasnik, Melissa A., Lupardus, Patrick J.
Publicado em 2014

Structure of the pseudokinase–kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition

Por Lupardus, Patrick J., Ultsch, Mark, Wallweber, Heidi, Bir Kohli, Pawan, Johnson, Adam R., Eigenbrot, Charles
Publicado em 2014

The Structural Basis for Class II Cytokine Receptor Recognition by JAK1

Por Ferrao, Ryan, Wallweber, Heidi J.A., Ho, Hoangdung, Tam, Christine, Franke, Yvonne, Quinn, John, Lupardus, Patrick J.
Publicado no Structure (2016)

Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP

Por Vucic, Domagoj, Franklin, Matthew C., Wallweber, Heidi J. A., Das, Kanad, Eckelman, Brendan P., Shin, Hwain, Elliott, Linda O., Kadkhodayan, Saloumeh, Deshayes, Kurt, Salvesen, Guy S., Fairbrother, Wayne J.
Publicado em 2004

Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action

Por René, Olivier, Fauber, Benjamin P., Boenig, Gladys de Leon, Burton, Brenda, Eidenschenk, Céline, Everett, Christine, Gobbi, Alberto, Hymowitz, Sarah G., Johnson, Adam R., Kiefer, James R., Liimatta, Marya, Lockey, Peter, Norman, Maxine, Ouyang, Wenjun, Wallweber, Heidi A., Wong, Harvey
Publicado no ACS Med Chem Lett (2014)

GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile

Por Villemure, Elisia, Volgraf, Matthew, Jiang, Yu, Wu, Guosheng, Ly, Cuong Q., Yuen, Po-wai, Lu, Aijun, Luo, Xifeng, Liu, Mingcui, Zhang, Shun, Lupardus, Patrick J., Wallweber, Heidi J. A., Liederer, Bianca M., Deshmukh, Gauri, Plise, Emile, Tay, Suzanne, Wang, Tzu-Ming, Hanson, Jesse E., Hackos, David H., Scearce-Levie, Kimberly, Schwarz, Jacob B., Sellers, Benjamin D.
Publicado no ACS Med Chem Lett (2016)

The Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)

Por Flygare, John A., Beresini, Maureen, Budha, Nageshwar, Chan, Helen, Chan, Iris T., Cheeti, Sravanthi, Cohen, Frederick, Deshayes, Kurt, Doerner, Karl, Eckhardt, S. Gail, Elliott, Linda O., Feng, Bainian, Franklin, Matthew C., Reisner, Stacy Frankovitz, Gazzard, Lewis, Halladay, Jason, Hymowitz, Sarah G., La, Hank, LoRusso, Patricia, Maurer, Brigitte, Murray, Lesley, Plise, Emile, Quan, Clifford, Stephan, Jean-Philippe, Shin, Young G., Tom, Jeffrey, Tsui, Vickie, Um, Joanne, Varfolomeev, Eugene, Vucic, Domagoj, Wagner, Andrew J., Wallweber, Heidi J.A., Wang, Lan, Ware, Joseph, Wen, Zhaoyang, Wong, Harvey, Wong, Jonathan M., Wong, Melisa, Wong, Susan, Yu, Ron, Zobel, Kerry, Fairbrother, Wayne J.
Publicado em 2012