Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action

[Image: see text] A minor structural change to tertiary sulfonamide RORc ligands led to distinct mechanisms of action. Co-crystal structures of two compounds revealed mechanistically consistent protein conformational changes. Optimized phenylsulfonamides were identified as RORc agonists while benzyl...

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書誌詳細
出版年:ACS Med Chem Lett
主要な著者: René, Olivier, Fauber, Benjamin P., Boenig, Gladys de Leon, Burton, Brenda, Eidenschenk, Céline, Everett, Christine, Gobbi, Alberto, Hymowitz, Sarah G., Johnson, Adam R., Kiefer, James R., Liimatta, Marya, Lockey, Peter, Norman, Maxine, Ouyang, Wenjun, Wallweber, Heidi A., Wong, Harvey
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2014
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360161/
https://ncbi.nlm.nih.gov/pubmed/25815138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500420y
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