Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action

[Image: see text] A minor structural change to tertiary sulfonamide RORc ligands led to distinct mechanisms of action. Co-crystal structures of two compounds revealed mechanistically consistent protein conformational changes. Optimized phenylsulfonamides were identified as RORc agonists while benzyl...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: René, Olivier, Fauber, Benjamin P., Boenig, Gladys de Leon, Burton, Brenda, Eidenschenk, Céline, Everett, Christine, Gobbi, Alberto, Hymowitz, Sarah G., Johnson, Adam R., Kiefer, James R., Liimatta, Marya, Lockey, Peter, Norman, Maxine, Ouyang, Wenjun, Wallweber, Heidi A., Wong, Harvey
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360161/
https://ncbi.nlm.nih.gov/pubmed/25815138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500420y
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