<it>p</it>HUSH: a single vector system for conditional gene expression

Por Eby Mike, Murray Lesley J, Gogineni Alvin, Gu Zhenyu, Peng Li, Hoeflich Klaus P, Gray Daniel C, Kljavin Noelyn, Seshagiri Somasekar, Cole Mary J, Davis David P
Publicado em 2007-09-01

pHUSH: a single vector system for conditional gene expression

Por Gray, Daniel C, Hoeflich, Klaus P, Peng, Li, Gu, Zhenyu, Gogineni, Alvin, Murray, Lesley J, Eby, Mike, Kljavin, Noelyn, Seshagiri, Somasekar, Cole, Mary J, Davis, David P
Publicado em 2007

Leveraging the Pre-DFG Residue Thr-406 To Obtain High Kinase Selectivity in an Aminopyrazole-Type PAK1 Inhibitor Series

Por Rudolph, Joachim, Aliagas, Ignacio, Crawford, James J., Mathieu, Simon, Lee, Wendy, Chao, Qi, Dong, Ping, Rouge, Lionel, Wang, Weiru, Heise, Christopher, Murray, Lesley J., La, Hank, Liu, Yanzhou, Manning, Gerard, Diederich, François, Hoeflich, Klaus P.
Publicado no ACS Med Chem Lett (2015)

Rate-Determining and Rate-Limiting Steps in the Clearance and Excretion of a Potent and Selective p21-Activated Kinase Inhibitor: A Case Study of Rapid Hepatic Uptake and Slow Elim...

Por Fan, Peter W., Chen, Jacob Z., Jaochico, M. Allan, La, Hank, Liu, Ning, Mulder, Teresa, Cass, Robert T., Durk, Matthew, Messick, Kirsten, Valle, Nicole, Liu, Shannon, Lee, Wendy, Crawford, James J., Rudolph, Joachim, Murray, Lesley J., Khojasteh, S. Cyrus, Wright, Matthew
Publicado no Drug Metab Lett (2016)

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

Por Degtyarev, Michael, De Mazière, Ann, Orr, Christine, Lin, Jie, Lee, Brian B., Tien, Janet Y., Prior, Wei W., van Dijk, Suzanne, Wu, Hong, Gray, Daniel C., Davis, David P., Stern, Howard M., Murray, Lesley J., Hoeflich, Klaus P., Klumperman, Judith, Friedman, Lori S., Lin, Kui
Publicado em 2008

Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis

Por Ndubaku, Chudi O., Crawford, Terry D., Chen, Huifen, Boggs, Jason W., Drobnick, Joy, Harris, Seth F., Jesudason, Rajiv, McNamara, Erin, Nonomiya, Jim, Sambrone, Amy, Schmidt, Stephen, Smyczek, Tanya, Vitorino, Philip, Wang, Lan, Wu, Ping, Yeung, Stacey, Chen, Jinhua, Chen, Kevin, Ding, Charles Z., Wang, Tao, Xu, Zijin, Gould, Stephen E., Murray, Lesley J., Ye, Weilan
Publicado no ACS Med Chem Lett (2015)

Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK(a) Polar Moiety

Por Ndubaku, Chudi O., Crawford, James J., Drobnick, Joy, Aliagas, Ignacio, Campbell, David, Dong, Ping, Dornan, Laura M., Duron, Sergio, Epler, Jennifer, Gazzard, Lewis, Heise, Christopher E., Hoeflich, Klaus P., Jakubiak, Diana, La, Hank, Lee, Wendy, Lin, Baiwei, Lyssikatos, Joseph P., Maksimoska, Jasna, Marmorstein, Ronen, Murray, Lesley J., O’Brien, Thomas, Oh, Angela, Ramaswamy, Sreemathy, Wang, Weiru, Zhao, Xianrui, Zhong, Yu, Blackwood, Elizabeth, Rudolph, Joachim
Publicado no ACS Med Chem Lett (2015)

The Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)

Por Flygare, John A., Beresini, Maureen, Budha, Nageshwar, Chan, Helen, Chan, Iris T., Cheeti, Sravanthi, Cohen, Frederick, Deshayes, Kurt, Doerner, Karl, Eckhardt, S. Gail, Elliott, Linda O., Feng, Bainian, Franklin, Matthew C., Reisner, Stacy Frankovitz, Gazzard, Lewis, Halladay, Jason, Hymowitz, Sarah G., La, Hank, LoRusso, Patricia, Maurer, Brigitte, Murray, Lesley, Plise, Emile, Quan, Clifford, Stephan, Jean-Philippe, Shin, Young G., Tom, Jeffrey, Tsui, Vickie, Um, Joanne, Varfolomeev, Eugene, Vucic, Domagoj, Wagner, Andrew J., Wallweber, Heidi J.A., Wang, Lan, Ware, Joseph, Wen, Zhaoyang, Wong, Harvey, Wong, Jonathan M., Wong, Melisa, Wong, Susan, Yu, Ron, Zobel, Kerry, Fairbrother, Wayne J.
Publicado em 2012