Competition between intercellular adhesion molecule-1 and a small-molecule antagonist for a common binding site on the αl subunit of lymphocyte function-associated antigen-1

gan Keating, Susan M., Clark, Kevin R., Stefanich, Lisa D., Arellano, Fred, Edwards, Caroline P., Bodary, Sarah C., Spencer, Steven A., Gadek, Thomas R., Marsters, James C., Beresini, Maureen H.
Cyhoeddwyd 2006

Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors

gan Chernov-Rogan, Tania, Li, Tianbo, Lu, Gang, Verschoof, Henry, Khakh, Kuldip, Jones, Steven W., Beresini, Maureen H., Liu, Chang, Ortwine, Daniel F., McKerrall, Steven J., Hackos, David H., Sutherlin, Daniel, Cohen, Charles J., Chen, Jun
Cyhoeddwyd yn Proc Natl Acad Sci U S A (2018)

Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells

gan Koehler, Michael F. T., Bergeron, Philippe, Blackwood, Elizabeth M., Bowman, Krista, Clark, Kevin R., Firestein, Ron, Kiefer, James R., Maskos, Klaus, McCleland, Mark L., Orren, Linda, Salphati, Laurent, Schmidt, Steve, Schneider, Elisabeth V., Wu, Jiansheng, Beresini, Maureen H.
Cyhoeddwyd yn ACS Med Chem Lett (2016)

Design and Development of a Series of Potent and Selective Type II Inhibitors of CDK8

gan Bergeron, Philippe, Koehler, Michael F. T., Blackwood, Elizabeth M., Bowman, Krista, Clark, Kevin, Firestein, Ron, Kiefer, James R., Maskos, Klaus, McCleland, Mark L., Orren, Linda, Ramaswamy, Sreemathy, Salphati, Laurent, Schmidt, Steve, Schneider, Elisabeth V., Wu, Jiansheng, Beresini, Maureen
Cyhoeddwyd yn ACS Med Chem Lett (2016)

Identification of BRaf-Sparing Amino-Thienopyrimidines with Potent IRE1α Inhibitory Activity

gan Beveridge, Ramsay E., Wallweber, Heidi Ackerly, Ashkenazi, Avi, Beresini, Maureen, Clark, Kevin R., Gibbons, Paul, Ghiro, Elise, Kaufman, Susan, Larivée, Alexandre, Leblanc, Melissa, Leclerc, Jean-Philippe, Lemire, Alexandre, Ly, Cuong, Rudolph, Joachim, Schwarz, Jacob B., Srivastava, Sanjay, Wang, Weiru, Zhao, Liang, Braun, Marie-Gabrielle
Cyhoeddwyd yn ACS Med Chem Lett (2020)

Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands

gan Ferri, Elena, Le Thomas, Adrien, Wallweber, Heidi Ackerly, Day, Eric S., Walters, Benjamin T., Kaufman, Susan E., Braun, Marie-Gabrielle, Clark, Kevin R., Beresini, Maureen H., Mortara, Kyle, Chen, Yung-Chia A., Canter, Breanna, Phung, Wilson, Liu, Peter S., Lammens, Alfred, Ashkenazi, Avi, Rudolph, Joachim, Wang, Weiru
Cyhoeddwyd yn Nat Commun (2020)

Disruption of IRE1α through its kinase domain attenuates multiple myeloma

gan Harnoss, Jonathan M., Le Thomas, Adrien, Shemorry, Anna, Marsters, Scot A., Lawrence, David A., Lu, Min, Chen, Yung-Chia Ariel, Qing, Jing, Totpal, Klara, Kan, David, Segal, Ehud, Merchant, Mark, Reichelt, Mike, Ackerly Wallweber, Heidi, Wang, Weiru, Clark, Kevin, Kaufman, Susan, Beresini, Maureen H., Laing, Steven T., Sandoval, Wendy, Lorenzo, Maria, Wu, Jiansheng, Ly, Justin, De Bruyn, Tom, Heidersbach, Amy, Haley, Benjamin, Gogineni, Alvin, Weimer, Robby M., Lee, Dong, Braun, Marie-Gabrielle, Rudolph, Joachim, VanWyngarden, Michael J., Sherbenou, Daniel W., Gomez-Bougie, Patricia, Amiot, Martine, Acosta-Alvear, Diego, Walter, Peter, Ashkenazi, Avi
Cyhoeddwyd yn Proc Natl Acad Sci U S A (2019)

The Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)

gan Flygare, John A., Beresini, Maureen, Budha, Nageshwar, Chan, Helen, Chan, Iris T., Cheeti, Sravanthi, Cohen, Frederick, Deshayes, Kurt, Doerner, Karl, Eckhardt, S. Gail, Elliott, Linda O., Feng, Bainian, Franklin, Matthew C., Reisner, Stacy Frankovitz, Gazzard, Lewis, Halladay, Jason, Hymowitz, Sarah G., La, Hank, LoRusso, Patricia, Maurer, Brigitte, Murray, Lesley, Plise, Emile, Quan, Clifford, Stephan, Jean-Philippe, Shin, Young G., Tom, Jeffrey, Tsui, Vickie, Um, Joanne, Varfolomeev, Eugene, Vucic, Domagoj, Wagner, Andrew J., Wallweber, Heidi J.A., Wang, Lan, Ware, Joseph, Wen, Zhaoyang, Wong, Harvey, Wong, Jonathan M., Wong, Melisa, Wong, Susan, Yu, Ron, Zobel, Kerry, Fairbrother, Wayne J.
Cyhoeddwyd 2012

Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637)

gan Taylor, Alexander M., Côté, Alexandre, Hewitt, Michael C., Pastor, Richard, Leblanc, Yves, Nasveschuk, Christopher G., Romero, F. Anthony, Crawford, Terry D., Cantone, Nico, Jayaram, Hariharan, Setser, Jeremy, Murray, Jeremy, Beresini, Maureen H., de Leon Boenig, Gladys, Chen, Zhongguo, Conery, Andrew R., Cummings, Richard T., Dakin, Leslie A., Flynn, E. Megan, Huang, Oscar W., Kaufman, Susan, Keller, Patricia J., Kiefer, James R., Lai, Tommy, Li, Yingjie, Liao, Jiangpeng, Liu, Wenfeng, Lu, Henry, Pardo, Eneida, Tsui, Vickie, Wang, Jian, Wang, Yongyun, Xu, Zhaowu, Yan, Fen, Yu, Dong, Zawadzke, Laura, Zhu, Xiaoqin, Zhu, Xiaoyu, Sims, Robert J., Cochran, Andrea G., Bellon, Steve, Audia, James E., Magnuson, Steven, Albrecht, Brian K.
Cyhoeddwyd yn ACS Med Chem Lett (2016)