Delineation of a Fundamental α-Ketoheterocycle Substituent Effect For Use in the Design of Enzyme Inhibitors

Por Romero, F. Anthony, Hwang, Inkyu, Boger, Dale L.
Publicado em 2006

Total Synthesis of Piericidin A1 and B1 and Key Analogues

Por Schnermann, Martin J., Romero, F. Anthony, Hwang, Inkyu, Nakamaru-Ogiso, Eiko, Yagi, Takao, Boger, Dale L.
Publicado em 2006

Structure–Activity Relationships of α-Keto Oxazole Inhibitors of Fatty Acid Amide Hydrolase

Por Hardouin, Christophe, Kelso, Michael J., Romero, F. Anthony, Rayl, Thomas J., Leung, Donmienne, Hwang, Inkyu, Cravatt, Benjamin F., Boger, Dale L.
Publicado em 2007

Optimization of α-Ketooxazole Inhibitors of Fatty Acid Amide Hydrolase

Por Kimball, F. Scott, Romero, F. Anthony, Ezzili, Cyrine, Garfunkle, Joie, Rayl, Thomas J., Hochstatter, Dustin G., Hwang, Inkyu, Boger, Dale L.
Publicado em 2008

Potent and Selective α-Ketoheterocycle-Based Inhibitors of the Anandamide and Oleamide Catabolizing Enzyme, Fatty Acid Amide Hydrolase

Por Romero, F. Anthony, Du, Wu, Hwang, Inkyu, Rayl, Thomas J., Kimball, F. Scott, Leung, Donmienne, Hoover, Heather S., Apodaca, Richard L., Breitenbucher, J. Guy, Cravatt, Benjamin F., Boger, Dale L.
Publicado em 2007

Optimization of Preclinical Metabolism for Somatostatin Receptor Subtype 5-Selective Antagonists

Por Liu, Weiguo, Hussain, Zahid, Zang, Yi, Sweis, Ramzi F., Romero, F. Anthony, Finke, Paul E., Moningka, Remond, Bao, Jianming, Plotkin, Michael A., Shang, Jin, Dingley, Karen H., Salituro, Gino, Murphy, Beth Ann, Howard, Andrew D., Ujjainwalla, Feroze, Wood, Harold B., Duffy, Joseph L.
Publicado no ACS Med Chem Lett (2018)

Discovery of MK-8722: A Systemic, Direct Pan-Activator of AMP-Activated Protein Kinase

Por Feng, Danqing, Biftu, Tesfaye, Romero, F. Anthony, Kekec, Ahmet, Dropinski, James, Kassick, Andrew, Xu, Shiyao, Kurtz, Marc M., Gollapudi, Anantha, Shao, Qing, Yang, Xiaodong, Lu, Ku, Zhou, Gaochao, Kemp, Daniel, Myers, Robert W., Guan, Hong-Ping, Trujillo, Maria E., Li, Cai, Weber, Ann, Sebhat, Iyassu K.
Publicado no ACS Med Chem Lett (2017)

GNE-886: A Potent and Selective Inhibitor of the Cat Eye Syndrome Chromosome Region Candidate 2 Bromodomain (CECR2)

Por Crawford, Terry D., Audia, James E., Bellon, Steve, Burdick, Daniel J., Bommi-Reddy, Archana, Côté, Alexandre, Cummings, Richard T., Duplessis, Martin, Flynn, E. Megan, Hewitt, Michael, Huang, Hon-Ren, Jayaram, Hariharan, Jiang, Ying, Joshi, Shivangi, Kiefer, James R., Murray, Jeremy, Nasveschuk, Christopher G., Neiss, Arianne, Pardo, Eneida, Romero, F. Anthony, Sandy, Peter, Sims, Robert J., Tang, Yong, Taylor, Alexander M., Tsui, Vickie, Wang, Jian, Wang, Shumei, Wang, Yongyun, Xu, Zhaowu, Zawadzke, Laura, Zhu, Xiaoqin, Albrecht, Brian K., Magnuson, Steven R., Cochran, Andrea G.
Publicado no ACS Med Chem Lett (2017)

Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition

Por Ghosh, Srimoyee, Taylor, Alexander, Chin, Melissa, Huang, Hon-Ren, Conery, Andrew R., Mertz, Jennifer A., Salmeron, Andres, Dakle, Pranal J., Mele, Deanna, Cote, Alexandre, Jayaram, Hari, Setser, Jeremy W., Poy, Florence, Hatzivassiliou, Georgia, DeAlmeida-Nagata, Denise, Sandy, Peter, Hatton, Charlie, Romero, F. Anthony, Chiang, Eugene, Reimer, Thornik, Crawford, Terry, Pardo, Eneida, Watson, Venita G., Tsui, Vickie, Cochran, Andrea G., Zawadzke, Laura, Harmange, Jean-Christophe, Audia, James E., Bryant, Barbara M., Cummings, Richard T., Magnuson, Steven R., Grogan, Jane L., Bellon, Steve F., Albrecht, Brian K., Sims, Robert J., Lora, Jose M.
Publicado no J Biol Chem (2016)

Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637)

Por Taylor, Alexander M., Côté, Alexandre, Hewitt, Michael C., Pastor, Richard, Leblanc, Yves, Nasveschuk, Christopher G., Romero, F. Anthony, Crawford, Terry D., Cantone, Nico, Jayaram, Hariharan, Setser, Jeremy, Murray, Jeremy, Beresini, Maureen H., de Leon Boenig, Gladys, Chen, Zhongguo, Conery, Andrew R., Cummings, Richard T., Dakin, Leslie A., Flynn, E. Megan, Huang, Oscar W., Kaufman, Susan, Keller, Patricia J., Kiefer, James R., Lai, Tommy, Li, Yingjie, Liao, Jiangpeng, Liu, Wenfeng, Lu, Henry, Pardo, Eneida, Tsui, Vickie, Wang, Jian, Wang, Yongyun, Xu, Zhaowu, Yan, Fen, Yu, Dong, Zawadzke, Laura, Zhu, Xiaoqin, Zhu, Xiaoyu, Sims, Robert J., Cochran, Andrea G., Bellon, Steve, Audia, James E., Magnuson, Steven, Albrecht, Brian K.
Publicado no ACS Med Chem Lett (2016)