Optimization of Preclinical Metabolism for Somatostatin Receptor Subtype 5-Selective Antagonists

[Image: see text] A series of structurally diverse azaspirodecanone and spirooxazolidinone analogues were designed and synthesized as potent and selective somatostatin receptor subtype 5 (SSTR5) antagonists. Four optimized compounds each representing a subseries showed improvement in their metabolic...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Liu, Weiguo, Hussain, Zahid, Zang, Yi, Sweis, Ramzi F., Romero, F. Anthony, Finke, Paul E., Moningka, Remond, Bao, Jianming, Plotkin, Michael A., Shang, Jin, Dingley, Karen H., Salituro, Gino, Murphy, Beth Ann, Howard, Andrew D., Ujjainwalla, Feroze, Wood, Harold B., Duffy, Joseph L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6231188/
https://ncbi.nlm.nih.gov/pubmed/30429950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00306
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