Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma

Por Conery, Andrew R, Centore, Richard C, Neiss, Adrianne, Keller, Patricia J, Joshi, Shivangi, Spillane, Kerry L, Sandy, Peter, Hatton, Charlie, Pardo, Eneida, Zawadzke, Laura, Bommi-Reddy, Archana, Gascoigne, Karen E, Bryant, Barbara M, Mertz, Jennifer A, Sims, Robert J
Publicado no eLife (2016)

Correction: Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma

Por Conery, Andrew R, Centore, Richard C, Neiss, Adrianne, Keller, Patricia J, Joshi, Shivangi, Spillane, Kerry L, Sandy, Peter, Hatton, Charlie, Pardo, Eneida, Zawadzke, Laura, Bommi-Reddy, Archana, Gascoigne, Karen E, Bryant, Barbara M, Mertz, Jennifer A, Sims, Robert J
Publicado no eLife (2016)

An Alternative Approach to ChIP-Seq Normalization Enables Detection of Genome-Wide Changes in Histone H3 Lysine 27 Trimethylation upon EZH2 Inhibition

Por Egan, Brian, Yuan, Chih-Chi, Craske, Madeleine Lisa, Labhart, Paul, Guler, Gulfem D., Arnott, David, Maile, Tobias M., Busby, Jennifer, Henry, Chisato, Kelly, Theresa K., Tindell, Charles A., Jhunjhunwala, Suchit, Zhao, Feng, Hatton, Charlie, Bryant, Barbara M., Classon, Marie, Trojer, Patrick
Publicado no PLoS One (2016)

High-throughput mutation profiling of CTCL samples reveals KRAS and NRAS mutations sensitizing tumors toward inhibition of the RAS/RAF/MEK signaling cascade

Por Kießling, Michael K., Oberholzer, Patrick A., Mondal, Chandrani, Karpova, Maria B., Zipser, Marie C., Lin, William M., Girardi, Michael, MacConaill, Laura E., Kehoe, Sarah M., Hatton, Charlie, French, Lars E., Garraway, Levi A., Polier, Gernot, Süss, Dorothee, Klemke, Claus-Detlev, Krammer, Peter H., Gülow, Karsten, Dummer, Reinhard
Publicado em 2011

Regulation of GLI underlies a role for BET bromodomains in pancreatic cancer growth and the tumor microenvironment

Por Huang, Yinshi, Nahar, Sabikun, Nakagawa, Akifumi, Fernandez de Barrena, Maite G., Mertz, Jennifer A., Bryant, Barbara M., Adams, Curtis E., Mino-Kenudson, Mari, Von Alt, Kate N., Chang, Kevin, Conery, Andrew R., Hatton, Charlie, Sims, Robert J., Fernandez-Zapico, Martin E., Wang, Xingpeng, Lillemoe, Keith D., Castillo, Carlos Fernández-del, Warshaw, Andrew L., Thayer, Sarah P., Liss, Andrew S.
Publicado no Clin Cancer Res (2016)

Drug-sensitive FGFR2 mutations in endometrial carcinoma

Por Dutt, Amit, Salvesen, Helga B., Chen, Tzu-Hsiu, Ramos, Alex H., Onofrio, Robert C., Hatton, Charlie, Nicoletti, Richard, Winckler, Wendy, Grewal, Rupinder, Hanna, Megan, Wyhs, Nicolas, Ziaugra, Liuda, Richter, Daniel J., Trovik, Jone, Engelsen, Ingeborg B., Stefansson, Ingunn M., Fennell, Tim, Cibulskis, Kristian, Zody, Michael C., Akslen, Lars A., Gabriel, Stacey, Wong, Kwok-Kin, Sellers, William R., Meyerson, Matthew, Greulich, Heidi
Publicado em 2008

Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway

Por Lovejoy, Courtney A., Li, Wendi, Reisenweber, Steven, Thongthip, Supawat, Bruno, Joanne, de Lange, Titia, De, Saurav, Petrini, John H. J., Sung, Patricia A., Jasin, Maria, Rosenbluh, Joseph, Zwang, Yaara, Weir, Barbara A., Hatton, Charlie, Ivanova, Elena, Macconaill, Laura, Hanna, Megan, Hahn, William C., Lue, Neal F., Reddel, Roger R., Jiao, Yuchen, Kinzler, Kenneth, Vogelstein, Bert, Papadopoulos, Nickolas, Meeker, Alan K.
Publicado em 2012

Prospective Enterprise-Level Molecular Genotyping of a Cohort of Cancer Patients

Por MacConaill, Laura E., Garcia, Elizabeth, Shivdasani, Priyanka, Ducar, Matthew, Adusumilli, Ravali, Breneiser, Marc, Byrne, Mark, Chung, Lawrence, Conneely, Jodie, Crosby, Lauren, Garraway, Levi A., Gong, Xin, Hahn, William C., Hatton, Charlie, Kantoff, Philip W., Kluk, Michael, Kuo, Frank, Jia, Yonghui, Joshi, Ruchi, Longtine, Janina, Manning, Allison, Palescandolo, Emanuele, Sharaf, Nematullah, Sholl, Lynette, van Hummelen, Paul, Wade, Jacqueline, Wollinson, Bruce M., Zepf, Dimity, Rollins, Barrett J., Lindeman, Neal I.
Publicado em 2014

Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma

Por Beroukhim, Rameen, Getz, Gad, Nghiemphu, Leia, Barretina, Jordi, Hsueh, Teli, Linhart, David, Vivanco, Igor, Lee, Jeffrey C., Huang, Julie H., Alexander, Sethu, Du, Jinyan, Kau, Tweeny, Thomas, Roman K., Shah, Kinjal, Soto, Horacio, Perner, Sven, Prensner, John, Debiasi, Ralph M., Demichelis, Francesca, Hatton, Charlie, Rubin, Mark A., Garraway, Levi A., Nelson, Stan F., Liau, Linda, Mischel, Paul S., Cloughesy, Tim F., Meyerson, Matthew, Golub, Todd A., Lander, Eric S., Mellinghoff, Ingo K., Sellers, William R.
Publicado em 2007

Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition

Por Ghosh, Srimoyee, Taylor, Alexander, Chin, Melissa, Huang, Hon-Ren, Conery, Andrew R., Mertz, Jennifer A., Salmeron, Andres, Dakle, Pranal J., Mele, Deanna, Cote, Alexandre, Jayaram, Hari, Setser, Jeremy W., Poy, Florence, Hatzivassiliou, Georgia, DeAlmeida-Nagata, Denise, Sandy, Peter, Hatton, Charlie, Romero, F. Anthony, Chiang, Eugene, Reimer, Thornik, Crawford, Terry, Pardo, Eneida, Watson, Venita G., Tsui, Vickie, Cochran, Andrea G., Zawadzke, Laura, Harmange, Jean-Christophe, Audia, James E., Bryant, Barbara M., Cummings, Richard T., Magnuson, Steven R., Grogan, Jane L., Bellon, Steve F., Albrecht, Brian K., Sims, Robert J., Lora, Jose M.
Publicado no J Biol Chem (2016)

Subtype-specific genomic alterations define new targets for soft tissue sarcoma therapy

Por Barretina, Jordi, Taylor, Barry S., Banerji, Shantanu, Ramos, Alexis H., Lagos-Quintana, Mariana, DeCarolis, Penelope L., Shah, Kinjal, Socci, Nicholas D., Weir, Barbara A., Ho, Alan, Chiang, Derek Y., Reva, Boris, Mermel, Craig, Getz, Gad, Antipin, Yevgenyi, Beroukhim, Rameen, Major, John E., Hatton, Charlie, Nicoletti, Richard, Hanna, Megan, Sharpe, Ted, Fennell, Tim, Cibulskis, Kristian, Onofrio, Robert C., Saito, Tsuyoshi, Shukla, Neerav, Lau, Christopher, Nelander, Sven, Silver, Serena, Sougnez, Carrie, Viale, Agnes, Winckler, Wendy, Maki, Robert G., Garraway, Levi A., Lash, Alex, Greulich, Heidi, Root, David, Sellers, William R., Schwartz, Gary K., Antonescu, Cristina R., Lander, Eric S., Varmus, Harold E., Ladanyi, Marc, Sander, Chris, Meyerson, Matthew, Singer, Samuel
Publicado em 2010