Regulation of GLI underlies a role for BET bromodomains in pancreatic cancer growth and the tumor microenvironment

PURPOSE: The initiation, progression, and maintenance of pancreatic ductal adenocarcinoma (PDAC) results from the interplay of genetic and epigenetic events. While the genetic alterations of PDAC have been well characterized, epigenetic pathways regulating PDAC remain, for the most part, elusive. Th...

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Gepubliceerd in:Clin Cancer Res
Hoofdauteurs: Huang, Yinshi, Nahar, Sabikun, Nakagawa, Akifumi, Fernandez de Barrena, Maite G., Mertz, Jennifer A., Bryant, Barbara M., Adams, Curtis E., Mino-Kenudson, Mari, Von Alt, Kate N., Chang, Kevin, Conery, Andrew R., Hatton, Charlie, Sims, Robert J., Fernandez-Zapico, Martin E., Wang, Xingpeng, Lillemoe, Keith D., Castillo, Carlos Fernández-del, Warshaw, Andrew L., Thayer, Sarah P., Liss, Andrew S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987213/
https://ncbi.nlm.nih.gov/pubmed/27169995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2068
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