Selective and reversible suppression of intestinal stem cell differentiation by pharmacological inhibition of BET bromodomains

Absorptive and secretory cells of the small intestine are derived from a single population of Lgr5-expressing stem cells. While key genetic pathways required for differentiation into specific lineages have been defined, epigenetic programs contributing to this process remain poorly characterized. Me...

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Udgivet i:Sci Rep
Main Authors: Nakagawa, Akifumi, Adams, Curtis E., Huang, Yinshi, Hamarneh, Sulaiman R., Liu, Wei, Von Alt, Kate N., Mino-Kenudson, Mari, Hodin, Richard A., Lillemoe, Keith D., Fernández-del Castillo, Carlos, Warshaw, Andrew L., Liss, Andrew S.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4746593/
https://ncbi.nlm.nih.gov/pubmed/26856877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20390
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