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Selective and reversible suppression of intestinal stem cell differentiation by pharmacological inhibition of BET bromodomains
Absorptive and secretory cells of the small intestine are derived from a single population of Lgr5-expressing stem cells. While key genetic pathways required for differentiation into specific lineages have been defined, epigenetic programs contributing to this process remain poorly characterized. Me...
Enregistré dans:
| Publié dans: | Sci Rep |
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| Auteurs principaux: | , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4746593/ https://ncbi.nlm.nih.gov/pubmed/26856877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20390 |
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