Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains

Targeting bromodomains (BRDs) of the bromo-and-extra-terminal (BET) family offers opportunities for therapeutic intervention in cancer and other diseases. Here, we profile the interactomes of BRD2, BRD3, BRD4, and BRDT following treatment with the pan-BET BRD inhibitor JQ1, revealing broad rewiring...

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Publicat a:Mol Cell
Autors principals: Lambert, Jean-Philippe, Picaud, Sarah, Fujisawa, Takao, Hou, Huayun, Savitsky, Pavel, Uusküla-Reimand, Liis, Gupta, Gagan D., Abdouni, Hala, Lin, Zhen-Yuan, Tucholska, Monika, Knight, James D.R., Gonzalez-Badillo, Beatriz, St-Denis, Nicole, Newman, Joseph A., Stucki, Manuel, Pelletier, Laurence, Bandeira, Nuno, Wilson, Michael D., Filippakopoulos, Panagis, Gingras, Anne-Claude
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6375729/
https://ncbi.nlm.nih.gov/pubmed/30554943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.11.006
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