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Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family

Benzodiazepines are psychoactive drugs with anxiolytic, sedative, skeletal muscle relaxant and amnestic properties. Recently triazolo-benzodiazepines have been also described as potent and highly selective protein interaction inhibitors of bromodomain and extra-terminal (BET) proteins, a family of t...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Bioorg Med Chem
Päätekijät: Filippakopoulos, Panagis, Picaud, Sarah, Fedorov, Oleg, Keller, Marco, Wrobel, Matthias, Morgenstern, Olaf, Bracher, Franz, Knapp, Stefan
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Elsevier Science 2012
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4748212/
https://ncbi.nlm.nih.gov/pubmed/22137933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.10.080
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