The Gramine Route to Pyrido[4,3-b]indol-3-ones – Identification of a New Cytotoxic Lead

Por Wollein, Uwe, Bracher, Franz
Publicado em 2011

New Perspectives in the Chemistry of Marine Pyridoacridine Alkaloids †

Por Plodek, Alois, Bracher, Franz
Publicado no Mar Drugs (2016)

A novel approach to oxoisoaporphine alkaloids via regioselective metalation of alkoxy isoquinolines

Por Melzer, Benedikt C, Bracher, Franz
Publicado no Beilstein J Org Chem (2017)

7-Aza-des-A-steroids with Antimicrobial and Cytotoxic Activity

Por Krojer, Melanie, Keller, Marco, Bracher, Franz
Publicado em 2013

New Substituted Isocoumarins and Dihydroisocoumarins and their Cytotoxic Activities

Por Hampl, Veronika, Wetzel, Isolde, Bracher, Franz, Krauss, Jürgen
Publicado em 2011

Synthesis by Ring-Closing Metathesis and Cytotoxic Evaluation of Novel Thienylmacrolactones

Por Krauss, Jürgen, Köbler, Daniela, Miller, Verena, Bracher, Franz
Publicado em 2012

Short and Efficient Synthesis of Alkyl- and Aryl-Ortho-Hydroxy-Anilides and their Antibiotic Activity

Por Krauß, Jürgen, Plesch, Eva, Clausen, Sabine, Bracher, Franz
Publicado no Sci Pharm (2014)

Aminomethylation/hydrogenolysis as an alternative to direct methylation of metalated isoquinolines – a novel total synthesis of the alkaloid 7-hydroxy-6-methoxy-1-methylisoquinolin...

Por Melzer, Benedikt C, Felber, Jan G, Bracher, Franz
Publicado no Beilstein J Org Chem (2018)

PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers

Por Brault, Laurent, Gasser, Christelle, Bracher, Franz, Huber, Kilian, Knapp, Stefan, Schwaller, Jürg
Publicado em 2010

Selectivity Profiling and Biological Activity of Novel β-Carbolines as Potent and Selective DYRK1 Kinase Inhibitors

Por Rüben, Katharina, Wurzlbauer, Anne, Walte, Agnes, Sippl, Wolfgang, Bracher, Franz, Becker, Walter
Publicado no PLoS One (2015)

Synthesis and Antifungal Evaluation of Novel N-Alkyl Tetra- and Perhydroquinoline Derivatives

Por Krauß, Jürgen, Hornacek, Michal, MÜller, Christoph, Staudacher, Verena, Stadler, Martina, Bracher, Franz
Publicado no Sci Pharm (2015)

Synthesis and Biological Evaluation of Novel Alkyl-Imidazolyl Carbinols and their Esters: Potent Antimycotics

Por Krauss, Jürgen, Gratzl, Carina, Sturm, Verena, Müller, Christoph, Staudacher, Verena, Schmidt, Christoph Q., Bracher, Franz
Publicado em 2013

Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family

Por Filippakopoulos, Panagis, Picaud, Sarah, Fedorov, Oleg, Keller, Marco, Wrobel, Matthias, Morgenstern, Olaf, Bracher, Franz, Knapp, Stefan
Publicado no Bioorg Med Chem (2012)

Functional Role and Therapeutic Potential of the Pim-1 Kinase in Colon Carcinoma

Por Weirauch, Ulrike, Beckmann, Nadine, Thomas, Maren, Grünweller, Arnold, Huber, Kilian, Bracher, Franz, Hartmann, Roland K, Aigner, Achim
Publicado em 2013

Schistosoma mansoni Sirtuins: Characterization and Potential as Chemotherapeutic Targets

Por Lancelot, Julien, Caby, Stéphanie, Dubois-Abdesselem, Florence, Vanderstraete, Mathieu, Trolet, Jacques, Oliveira, Guilherme, Bracher, Franz, Jung, Manfred, Pierce, Raymond J.
Publicado em 2013

An Antifungal Benzimidazole Derivative Inhibits Ergosterol Biosynthesis and Reveals Novel Sterols

Por Keller, Petra, Müller, Christoph, Engelhardt, Isabel, Hiller, Ekkehard, Lemuth, Karin, Eickhoff, Holger, Wiesmüller, Karl-Heinz, Burger-Kentischer, Anke, Bracher, Franz, Rupp, Steffen
Publicado no Antimicrob Agents Chemother (2015)

7,8-Dichloro-1-oxo-β-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding Modes†

Por Huber, Kilian, Brault, Laurent, Fedorov, Oleg, Gasser, Christelle, Filippakopoulos, Panagis, Bullock, Alex N., Fabbro, Doriano, Trappe, Jörg, Schwaller, Jürg, Knapp, Stefan, Bracher, Franz
Publicado em 2011

Inhibition of endothelial Cdk5 reduces tumor growth by promoting non-productive angiogenesis

Por Merk, Henriette, Zhang, Siwei, Lehr, Thorsten, Müller, Christoph, Ulrich, Melanie, Bibb, James A., Adams, Ralf H., Bracher, Franz, Zahler, Stefan, Vollmar, Angelika M., Liebl, Johanna
Publicado no Oncotarget (2016)

Antifungal defense of probiotic Lactobacillus rhamnosus GG is mediated by blocking adhesion and nutrient depletion

Por Mailänder-Sánchez, Daniela, Braunsdorf, Christina, Grumaz, Christian, Müller, Christoph, Lorenz, Stefan, Stevens, Philip, Wagener, Jeanette, Hebecker, Betty, Hube, Bernhard, Bracher, Franz, Sohn, Kai, Schaller, Martin
Publicado no PLoS One (2017)

Atypical antipsychotics alter cholesterol and fatty acid metabolism in vitro

Por Canfrán-Duque, Alberto, Casado, María E., Pastor, Óscar, Sánchez-Wandelmer, Jana, de la Peña, Gema, Lerma, Milagros, Mariscal, Paloma, Bracher, Franz, Lasunción, Miguel A., Busto, Rebeca
Publicado em 2013