Schistosoma mansoni Sirtuins: Characterization and Potential as Chemotherapeutic Targets

BACKGROUND: The chemotherapy of schistosomiasis currently depends on the use of a single drug, praziquantel. In order to develop novel chemotherapeutic agents we are investigating enzymes involved in the epigenetic modification of chromatin. Sirtuins are NAD+ dependent lysine deacetylases that are i...

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Detalhes bibliográficos
Main Authors: Lancelot, Julien, Caby, Stéphanie, Dubois-Abdesselem, Florence, Vanderstraete, Mathieu, Trolet, Jacques, Oliveira, Guilherme, Bracher, Franz, Jung, Manfred, Pierce, Raymond J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772001/
https://ncbi.nlm.nih.gov/pubmed/24069483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002428
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