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Schistosoma mansoni Sirtuins: Characterization and Potential as Chemotherapeutic Targets
BACKGROUND: The chemotherapy of schistosomiasis currently depends on the use of a single drug, praziquantel. In order to develop novel chemotherapeutic agents we are investigating enzymes involved in the epigenetic modification of chromatin. Sirtuins are NAD+ dependent lysine deacetylases that are i...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3772001/ https://ncbi.nlm.nih.gov/pubmed/24069483 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002428 |
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