PI3K/mTOR Pathway Inhibition: Opportunities in Oncology and Rare Genetic Diseases

per Hillmann, Petra, Fabbro, Doriano
Publicat a Int J Mol Sci (2019)

Ten things you should know about protein kinases: IUPHAR Review 14

per Fabbro, Doriano, Cowan-Jacob, Sandra W, Moebitz, Henrik
Publicat a Br J Pharmacol (2015)

Targeting Sphingosine Kinase 1 in Carcinoma Cells Decreases Proliferation and Survival by Compromising PKC Activity and Cytokinesis

per Kotelevets, Nataliya, Fabbro, Doriano, Huwiler, Andrea, Zangemeister-Wittke, Uwe
Publicat 2012

Correction: Targeting Sphingosine Kinase 1 in Carcinoma Cells Decreases Proliferation and Survival by Compromising PKC Activity and Cytokinesis

per Kotelevets, Nataliya, Fabbro, Doriano, Huwiler, Andrea, Zangemeister-Wittke, Uwe
Publicat 2013

NMR reveals the allosteric opening and closing of Abelson tyrosine kinase by ATP-site and myristoyl pocket inhibitors

per Skora, Lukasz, Mestan, Jürgen, Fabbro, Doriano, Jahnke, Wolfgang, Grzesiek, Stephan
Publicat 2013

Phosphorylation, Signaling, and Cancer: Targets and Targeting

per Marmiroli, Sandra, Fabbro, Doriano, Miyata, Yoshihiko, Pierobon, Mariaelena, Ruzzene, Maria
Publicat a Biomed Res Int (2015)

CSIG-26. MOLECULAR DETERMINANTS OF SENSITIVITY TO PI3K/AKT/mTOR PATHWAY INHIBITION IN GLIOBLASTOMA

per von Achenbach, Caroline, Weller, Michael, Kaulich, Kerstin, Gramatzki, Dorothee, Zacher, Angela, Fabbro, Doriano, Reifenberger, Guido, Szabo, Emese
Publicat a Neuro Oncol (2018)

Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412

per Growney, Joseph D., Clark, Jennifer J., Adelsperger, Jennifer, Stone, Richard, Fabbro, Doriano, Griffin, James D., Gilliland, D. Gary
Publicat 2005

The ceramide kinase inhibitor NVP-231 inhibits breast and lung cancer cell proliferation by inducing M phase arrest and subsequent cell death

per Pastukhov, Oleksandr, Schwalm, Stephanie, Zangemeister-Wittke, Uwe, Fabbro, Doriano, Bornancin, Frederic, Japtok, Lukasz, Kleuser, Burkhard, Pfeilschifter, Josef, Huwiler, Andrea
Publicat a Br J Pharmacol (2014)

Kinase Inhibition by Deoxy Analogues of the Resorcylic Lactone L-783277

per Liniger, Marc, Neuhaus, Christian, Hofmann, Tatjana, Fransioli-Ignazio, Luca, Jordi, Michel, Drueckes, Peter, Trappe, Jörg, Fabbro, Doriano, Altmann, Karl-Heinz
Publicat 2010

Stable expression of small interfering RNA sensitizes TEL-PDGFβR to inhibition with imatinib or rapamycin

per Chen, Jing, Wall, Nathan R., Kocher, Kerry, Duclos, Nicole, Fabbro, Doriano, Neuberg, Donna, Griffin, James D., Shi, Yang, Gilliland, D. Gary
Publicat 2004

RET/PTC INDUCED CELL GROWTH IS MEDIATED IN PART BY EPIDERMAL GROWTH RECEPTOR ACTIVATION: EVIDENCE FOR MOLECULAR AND FUNCTIONAL INTERACTIONS BETWEEN RET AND EGFR

per Croyle, Michelle, Akeno, Nagako, Knauf, Jeffrey A., Traxler, Peter, Fabbro, Doriano, Chen, Xu, Baumgartner, Jacqueline E., Lane, Heidi A., Fagin, James A.
Publicat a Cancer Res (2008)

Dramatic Inhibition of Retinal and Choroidal Neovascularization by Oral Administration of a Kinase Inhibitor

per Seo, Man Seong, Kwak, Nohoon, Ozaki, Hiroaki, Yamada, Haruhiko, Okamoto, Naoyuki, Yamada, Eri, Fabbro, Doriano, Hofmann, Francesco, Wood, Jeanette M., Campochiaro, Peter A.
Publicat 1999

Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia

per Cowan-Jacob, Sandra W., Fendrich, Gabriele, Floersheimer, Andreas, Furet, Pascal, Liebetanz, Janis, Rummel, Gabriele, Rheinberger, Paul, Centeleghe, Mario, Fabbro, Doriano, Manley, Paul W.
Publicat 2006

7,8-Dichloro-1-oxo-β-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding Modes†

per Huber, Kilian, Brault, Laurent, Fedorov, Oleg, Gasser, Christelle, Filippakopoulos, Panagis, Bullock, Alex N., Fabbro, Doriano, Trappe, Jörg, Schwaller, Jürg, Knapp, Stefan, Bracher, Franz
Publicat 2011

Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo

per Monia, Brett P., Sasmor, Henri, Johnston, Joseph F., Freier, Susan M., Lesnik, Elena A., Muller, Marcel, Geiger, Thomas, Altmann, Karl-Heinz, Moser, Heinz, Fabbro, Doriano
Publicat 1996

Preclinical Development of PQR514, a Highly Potent PI3K Inhibitor Bearing a Difluoromethyl–Pyrimidine Moiety

per Borsari, Chiara, Rageot, Denise, Beaufils, Florent, Bohnacker, Thomas, Keles, Erhan, Buslov, Ivan, Melone, Anna, Sele, Alexander M., Hebeisen, Paul, Fabbro, Doriano, Hillmann, Petra, Wymann, Matthias P.
Publicat a ACS Med Chem Lett (2019)

Specific CLK Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing

per Fedorov, Oleg, Huber, Kilian, Eisenreich, Andreas, Filippakopoulos, Panagis, King, Oliver, Bullock, Alex N., Szklarczyk, Damian, Jensen, Lars J., Fabbro, Doriano, Trappe, Jörg, Rauch, Ursula, Bracher, Franz, Knapp, Stefan
Publicat 2011

The Concise Guide to PHARMACOLOGY 2015/16: Catalytic receptors

per Alexander, Stephen PH, Fabbro, Doriano, Kelly, Eamonn, Marrion, Neil, Peters, John A, Benson, Helen E, Faccenda, Elena, Pawson, Adam J, Sharman, Joanna L, Southan, Christopher, Davies, Jamie A
Publicat a Br J Pharmacol (2015)

The Concise Guide to PHARMACOLOGY 2015/16: Enzymes

per Alexander, Stephen PH, Fabbro, Doriano, Kelly, Eamonn, Marrion, Neil, Peters, John A, Benson, Helen E, Faccenda, Elena, Pawson, Adam J, Sharman, Joanna L, Southan, Christopher, Davies, Jamie A
Publicat a Br J Pharmacol (2015)