Specific CLK Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing

There is a growing recognition of the importance of protein kinases in the control of alternative splicing. To define the underlying regulatory mechanisms, highly selective inhibitors are needed. Here, we report the discovery and characterization of the dichloroindolyl enaminonitrile KH-CB19, a pote...

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Hauptverfasser: Fedorov, Oleg, Huber, Kilian, Eisenreich, Andreas, Filippakopoulos, Panagis, King, Oliver, Bullock, Alex N., Szklarczyk, Damian, Jensen, Lars J., Fabbro, Doriano, Trappe, Jörg, Rauch, Ursula, Bracher, Franz, Knapp, Stefan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145970/
https://ncbi.nlm.nih.gov/pubmed/21276940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.11.009
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