Kinase Domain Insertions Define Distinct Roles of CLK Kinases in SR Protein Phosphorylation

Splicing requires reversible phosphorylation of serine/arginine-rich (SR) proteins, which direct splice site selection in eukaryotic mRNA. These phosphorylation events are dependent on SR protein (SRPK) and cdc2-like kinase (CLK) families. SRPK1 phosphorylation of splicing factors is restricted by a...

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Detalhes bibliográficos
Main Authors: Bullock, Alex N., Das, Sanjan, Debreczeni, Judit É., Rellos, Peter, Fedorov, Oleg, Niesen, Frank H., Guo, Kunde, Papagrigoriou, Evangelos, Amos, Ann L., Cho, Suhyung, Turk, Benjamin E., Ghosh, Gourisankar, Knapp, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667211/
https://ncbi.nlm.nih.gov/pubmed/19278650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2008.12.023
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