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A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases

Protein kinases play a pivotal role in cell signaling, and dysregulation of many kinases has been linked to disease development. A large number of kinase inhibitors are therefore currently under investigation in clinical trials, and so far seven inhibitors have been approved as anti-cancer drugs. In...

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Autors principals: Fedorov, Oleg, Marsden, Brian, Pogacic, Vanda, Rellos, Peter, Müller, Susanne, Bullock, Alex N., Schwaller, Juerg, Sundström, Michael, Knapp, Stefan
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2154464/
https://ncbi.nlm.nih.gov/pubmed/18077363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708800104
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