Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-competitive purine analogue

по Chène, Patrick, Rudloff, Joëlle, Schoepfer, Joseph, Furet, Pascal, Meier, Peter, Qian, Zhiyan, Schlaeppi, Jean-Marc, Schmitz, Rita, Radimerski, Thomas
Опубликовано 2009

Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes

по Kallen, Joerg, Goepfert, Arnaud, Blechschmidt, Anke, Izaac, Aude, Geiser, Martin, Tavares, Gisele, Ramage, Paul, Furet, Pascal, Masuya, Keiichi, Lisztwan, Joanna
Опубликовано 2009

The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis

по Martiny-Baron, Georg, Holzer, Philipp, Billy, Eric, Schnell, Christian, Brueggen, Joseph, Ferretti, Mireille, Schmiedeberg, Niko, Wood, Jeanette M., Furet, Pascal, Imbach, Patricia
Опубликовано 2010

2-Formylpyridyl Ureas as Highly Selective Reversible-Covalent Inhibitors of Fibroblast Growth Factor Receptor 4

по Knoepfel, Thomas, Furet, Pascal, Mah, Robert, Buschmann, Nicole, Leblanc, Catherine, Ripoche, Sebastien, Graus-Porta, Diana, Wartmann, Markus, Galuba, Inga, Fairhurst, Robin A.
Опубликовано в: ACS Med Chem Lett (2018)

Adaptation of the bound intrinsically disordered protein YAP to mutations at the YAP:TEAD interface

по Mesrouze, Yannick, Bokhovchuk, Fedir, Izaac, Aude, Meyerhofer, Marco, Zimmermann, Catherine, Fontana, Patrizia, Schmelzle, Tobias, Erdmann, Dirk, Furet, Pascal, Kallen, Joerg, Chène, Patrick
Опубликовано в: Protein Sci (2018)

Correction to “2-Formylpyridyl Ureas as Highly Selective Reversible-Covalent Inhibitors of Fibroblast Growth Factor Receptor 4”

по Knoepfel, Thomas, Furet, Pascal, Mah, Robert, Buschmann, Nicole, Leblanc, Catherine, Ripoche, Sebastien, Graus-Porta, Diana, Wartmann, Markus, Galuba, Inga, Fairhurst, Robin A.
Опубликовано в: ACS Med Chem Lett (2020)

Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia

по Cowan-Jacob, Sandra W., Fendrich, Gabriele, Floersheimer, Andreas, Furet, Pascal, Liebetanz, Janis, Rummel, Gabriele, Rheinberger, Paul, Centeleghe, Mario, Fabbro, Doriano, Manley, Paul W.
Опубликовано 2006

Antileukemic Effects of Novel First- and Second-Generation FLT3 Inhibitors: Structure-Affinity Comparison

по Weisberg, Ellen, Roesel, Johannes, Furet, Pascal, Bold, Guido, Imbach, Patricia, Flörsheimer, Andreas, Caravatti, Georgio, Jiang, Jingrui, Manley, Paul, Ray, Arghya, Griffin, James D.
Опубликовано 2010

Identification of FAM181A and FAM181B as new interactors with the TEAD transcription factors

по Bokhovchuk, Fedir, Mesrouze, Yannick, Delaunay, Clara, Martin, Typhaine, Villard, Frédéric, Meyerhofer, Marco, Fontana, Patrizia, Zimmermann, Catherine, Erdmann, Dirk, Furet, Pascal, Scheufler, Clemens, Schmelzle, Tobias, Chène, Patrick
Опубликовано в: Protein Sci (2019)

p53 dynamics vary between tissues and are linked with radiation sensitivity

по Stewart-Ornstein, Jacob, Iwamoto, Yoshiko, Miller, Miles A., Prytyskach, Mark A., Ferretti, Stephane, Holzer, Philipp, Kallen, Joerg, Furet, Pascal, Jambhekar, Ashwini, Forrester, William C., Weissleder, Ralph, Lahav, Galit
Опубликовано в: Nat Commun (2021)

Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA).

по Sarno, Stefania, de Moliner, Erika, Ruzzene, Maria, Pagano, Mario A, Battistutta, Roberto, Bain, Jenny, Fabbro, Doriano, Schoepfer, Joseph, Elliott, Matthew, Furet, Pascal, Meggio, Flavio, Zanotti, Giuseppe, Pinna, Lorenzo A
Опубликовано 2003

Approaches to selective fibroblast growth factor receptor 4 inhibition through targeting the ATP-pocket middle-hinge region

по Fairhurst, Robin A., Knoepfel, Thomas, Leblanc, Catherine, Buschmann, Nicole, Gaul, Christoph, Blank, Jutta, Galuba, Inga, Trappe, Jörg, Zou, Chao, Voshol, Johannes, Genick, Christine, Brunet-Lefeuvre, Peggy, Bitsch, Francis, Graus-Porta, Diana, Furet, Pascal
Опубликовано в: Medchemcomm (2017)

A new perspective on the interaction between the Vg/VGLL1-3 proteins and the TEAD transcription factors

по Mesrouze, Yannick, Aguilar, Gustavo, Bokhovchuk, Fedir, Martin, Typhaine, Delaunay, Clara, Villard, Frédéric, Meyerhofer, Marco, Zimmermann, Catherine, Fontana, Patrizia, Wille, Roman, Vorherr, Thomas, Erdmann, Dirk, Furet, Pascal, Scheufler, Clemens, Schmelzle, Tobias, Affolter, Markus, Chène, Patrick
Опубликовано в: Sci Rep (2020)

Discovery and Pharmacological Characterization of Novel Quinazoline-Based PI3K Delta-Selective Inhibitors

по Hoegenauer, Klemens, Soldermann, Nicolas, Stauffer, Frédéric, Furet, Pascal, Graveleau, Nadege, Smith, Alexander B., Hebach, Christina, Hollingworth, Gregory J., Lewis, Ian, Gutmann, Sascha, Rummel, Gabriele, Knapp, Mark, Wolf, Romain M., Blanz, Joachim, Feifel, Roland, Burkhart, Christoph, Zécri, Frédéric
Опубликовано в: ACS Med Chem Lett (2016)

Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy in Vivo

по Honda, Ayako, Harrington, Edmund, Cornella-Taracido, Ivan, Furet, Pascal, Knapp, Mark S., Glick, Meir, Triantafellow, Ellen, Dowdle, William E., Wiedershain, Dmitri, Maniara, Wieslawa, Moore, Christine, Finan, Peter M., Hamann, Lawrence G., Firestone, Brant, Murphy, Leon O., Keaney, Erin P.
Опубликовано в: ACS Med Chem Lett (2015)

Antileukemic effects of the novel, mutant FLT3 inhibitor NVP-AST487: effects on PKC412-sensitive and -resistant FLT3-expressing cells

по Weisberg, Ellen, Roesel, Johannes, Bold, Guido, Furet, Pascal, Jiang, Jingrui, Cools, Jan, Wright, Renee D., Nelson, Erik, Barrett, Rosemary, Ray, Arghya, Moreno, Daisy, Hall-Meyers, Elizabeth, Stone, Richard, Galinsky, Ilene, Fox, Edward, Gilliland, Gary, Daley, John F., Lazo-Kallanian, Suzan, Kung, Andrew L., Griffin, James D.
Опубликовано 2008

A distinct p53 target gene set predicts for response to the selective p53–HDM2 inhibitor NVP-CGM097

по Jeay, Sébastien, Gaulis, Swann, Ferretti, Stéphane, Bitter, Hans, Ito, Moriko, Valat, Thérèse, Murakami, Masato, Ruetz, Stephan, Guthy, Daniel A, Rynn, Caroline, Jensen, Michael R, Wiesmann, Marion, Kallen, Joerg, Furet, Pascal, Gessier, François, Holzer, Philipp, Masuya, Keiichi, Würthner, Jens, Halilovic, Ensar, Hofmann, Francesco, Sellers, William R, Graus Porta, Diana
Опубликовано в: eLife (2015)

Correction: A distinct p53 target gene set predicts for response to the selective p53-HDM2 inhibitor NVP-CGM097

по Jeay, Sébastien, Gaulis, Swann, Ferretti, Stéphane, Bitter, Hans, Ito, Moriko, Valat, Thérèse, Murakami, Masato, Ruetz, Stephan, Guthy, Daniel A, Rynn, Caroline, Jensen, Michael R, Wiesmann, Marion, Kallen, Joerg, Furet, Pascal, Gessier, François, Holzer, Philipp, Masuya, Keiichi, Würthner, Jens, Halilovic, Ensar, Hofmann, Francesco, Sellers, William R, Graus Porta, Diana
Опубликовано в: eLife (2016)

Polyclonal secondary FGFR2 mutations drive acquired resistance to FGFR inhibition in patients with FGFR2 fusion-positive cholangiocarcinoma

по Goyal, Lipika, Saha, Supriya K., Liu, Leah Y., Siravegna, Giulia, Leshchiner, Ignaty, Ahronian, Leanne G., Lennerz, Jochen K., Vu, Phuong, Deshpande, Vikram, Kambadakone, Avinash, Mussolin, Benedetta, Reyes, Stephanie, Henderson, Laura, Sun, Jiaoyuan Elisabeth, Van Seventer, Emily E., Gurski, Joseph M., Baltschukat, Sabrina, Schacher-Engstler, Barbara, Barys, Louise, Stamm, Christelle, Furet, Pascal, Ryan, David P., Stone, James R., Iafrate, A. John, Getz, Gad, Porta, Diana Graus, Tiedt, Ralph, Bardelli, Alberto, Juric, Dejan, Corcoran, Ryan B., Bardeesy, Nabeel, Zhu, Andrew X.
Опубликовано в: Cancer Discov (2016)