Genotyping cell-free tumor DNA in the blood to detect residual disease and drug resistance

Por Siravegna, Giulia, Bardelli, Alberto
Publicado no Genome Biol (2014)

Clonal evolution and KRAS-MET coamplification during secondary resistance to EGFR-targeted therapy in metastatic colorectal cancer

Por Sartore-Bianchi, Andrea, Valtorta, Emanuele, Amatu, Alessio, Veronese, Silvio, Lauricella, Calogero, Bonazzina, Erica, Siravegna, Giulia, Truini, Mauro, Bardelli, Alberto, Siena, Salvatore
Publicado no ESMO Open (2016)

Molecular heterogeneity and receptor co-amplification drive resistance to targeted therapy in MET-amplified esophagogastric cancer

Por Kwak, Eunice L., Ahronian, Leanne G., Siravegna, Giulia, Mussolin, Benedetta, Godfrey, Jason T., Clark, Jeffrey W., Blaszkowsky, Lawrence S., Ryan, David P., Lennerz, Jochen K., Iafrate, A. John, Bardelli, Alberto, Hong, Theodore S., Corcoran, Ryan B.
Publicado no Cancer Discov (2015)

Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer

Por Van Emburgh, Beth O., Arena, Sabrina, Siravegna, Giulia, Lazzari, Luca, Crisafulli, Giovanni, Corti, Giorgio, Mussolin, Benedetta, Baldi, Federica, Buscarino, Michela, Bartolini, Alice, Valtorta, Emanuele, Vidal, Joana, Bellosillo, Beatriz, Germano, Giovanni, Pietrantonio, Filippo, Ponzetti, Agostino, Albanell, Joan, Siena, Salvatore, Sartore-Bianchi, Andrea, Di Nicolantonio, Federica, Montagut, Clara, Bardelli, Alberto
Publicado no Nat Commun (2016)

Emergence of KRAS mutations and acquired resistance to anti EGFR therapy in colorectal cancer

Por Misale, Sandra, Yaeger, Rona, Hobor, Sebastijan, Scala, Elisa, Janakiraman, Manickam, Liska, David, Valtorta, Emanuele, Schiavo, Roberta, Buscarino, Michela, Siravegna, Giulia, Bencardino, Katia, Cercek, Andrea, Chen, Chin-Tung, Veronese, Silvio, Zanon, Carlo, Sartore-Bianchi, Andrea, Gambacorta, Marcello, Gallicchio, Margherita, Vakiani, Efsevia, Boscaro, Valentina, Medico, Enzo, Weiser, Martin, Siena, Salvatore, Di Nicolantonio, Federica, Solit, David, Bardelli, Alberto
Publicado em 2012

Tumor heterogeneity and lesion-specific response to targeted therapy in colorectal cancer

Por Russo, Mariangela, Siravegna, Giulia, Blaszkowsky, Lawrence S., Corti, Giorgio, Crisafulli, Giovanni, Ahronian, Leanne G., Mussolin, Benedetta, Kwak, Eunice L., Buscarino, Michela, Lazzari, Luca, Valtorta, Emanuele, Truini, Mauro, Jessop, Nicholas A., Robinson, Hayley E., Hong, Theodore S., Mino-Kenudson, Mari, Di Nicolantonio, Federica, Thabet, Ashraf, Sartore-Bianchi, Andrea, Siena, Salvatore, Iafrate, A. John, Bardelli, Alberto, Corcoran, Ryan B.
Publicado no Cancer Discov (2015)

Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer

Por Bardelli, Alberto, Corso, Simona, Bertotti, Andrea, Hobor, Sebastijan, Valtorta, Emanuele, Siravegna, Giulia, Sartore-Bianchi, Andrea, Scala, Elisa, Cassingena, Andrea, Zecchin, Davide, Apicella, Maria, Migliardi, Giorgia, Galimi, Francesco, Lauricella, Calogero, Zanon, Carlo, Perera, Timothy, Veronese, Silvio, Corti, Giorgio, Amatu, Alessio, Gambacorta, Marcello, Diaz, Luis A., Sausen, Mark, Velculescu, Victor E., Comoglio, Paolo, Trusolino, Livio, Di Nicolantonio, Federica, Giordano, Silvia, Siena, Salvatore
Publicado em 2013

Monitoring clonal evolution and resistance to EGFR blockade in the blood of metastatic colorectal cancer patients

Por Siravegna, Giulia, Mussolin, Benedetta, Buscarino, Michela, Corti, Giorgio, Cassingena, Andrea, Crisafulli, Giovanni, Ponzetti, Agostino, Cremolini, Chiara, Amatu, Alessio, Lauricella, Calogero, Lamba, Simona, Hobor, Sebastijan, Avallone, Antonio, Valtorta, Emanuele, Rospo, Giuseppe, Medico, Enzo, Motta, Valentina, Antoniotti, Carlotta, Tatangelo, Fabiana, Bellosillo, Beatriz, Veronese, Silvio, Budillon, Alfredo, Montagut, Clara, Racca, Patrizia, Marsoni, Silvia, Falcone, Alfredo, Corcoran, Ryan B., Di Nicolantonio, Federica, Loupakis, Fotios, Siena, Salvatore, Sartore-Bianchi, Andrea, Bardelli, Alberto
Publicado no Nat Med (2015)

Molecular landscape of acquired resistance to targeted therapy combinations in BRAF mutant colorectal cancer

Por Oddo, Daniele, Sennott, Erin M., Barault, Ludovic, Valtorta, Emanuele, Arena, Sabrina, Cassingena, Andrea, Filiciotto, Genny, Marzolla, Giulia, Elez, Elena, van Geel, Robin M.J.M., Bartolini, Alice, Crisafulli, Giovanni, Boscaro, Valentina, Godfrey, Jason T., Buscarino, Michela, Cancelliere, Carlotta, Linnebacher, Michael, Corti, Giorgio, Truini, Mauro, Siravegna, Giulia, Grasselli, Julieta, Gallicchio, Margherita, Bernards, René, Schellens, Jan H.M., Tabernero, Josep, Engelman, Jeffrey A., Sartore-Bianchi, Andrea, Bardelli, Alberto, Siena, Salvatore, Corcoran, Ryan B., Di Nicolantonio, Federica
Publicado no Cancer Res (2016)

Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition

Por Hata, Aaron N, Niederst, Matthew J, Archibald, Hannah L, Gomez-Caraballo, Maria, Siddiqui, Faria M, Mulvey, Hillary E, Maruvka, Yosef E, Ji, Fei, Bhang, Hyo-eun C, Radhakrishna, Viveksagar Krishnamurthy, Siravegna, Giulia, Hu, Haichuan, Raoof, Sana, Lockerman, Elizabeth, Kalsy, Anuj, Lee, Dana, Keating, Celina L, Ruddy, David A, Damon, Leah J, Crystal, Adam S, Costa, Carlotta, Piotrowska, Zofia, Bardelli, Alberto, Iafrate, Anthony J, Sadreyev, Ruslan I, Stegmeier, Frank, Getz, Gad, Sequist, Lecia V, Faber, Anthony C, Engelman, Jeffrey A
Publicado no Nat Med (2016)

Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

Por Bettegowda, Chetan, Sausen, Mark, Leary, Rebecca J., Kinde, Isaac, Wang, Yuxuan, Agrawal, Nishant, Bartlett, Bjarne R., Wang, Hao, Luber, Brandon, Alani, Rhoda M., Antonarakis, Emmanuel S., Azad, Nilofer S., Bardelli, Alberto, Brem, Henry, Cameron, John L., Lee, Clarence C., Fecher, Leslie A., Gallia, Gary L., Gibbs, Peter, Le, Dung, Giuntoli, Robert L., Goggins, Michael, Hogarty, Michael D., Holdhoff, Matthias, Hong, Seung-Mo, Jiao, Yuchen, Juhl, Hartmut H., Kim, Jenny J., Siravegna, Giulia, Laheru, Daniel A., Lauricella, Calogero, Lim, Michael, Lipson, Evan J., Marie, Suely Kazue Nagahashi, Netto, George J., Oliner, Kelly S., Olivi, Alessandro, Olsson, Louise, Riggins, Gregory J., Sartore-Bianchi, Andrea, Schmidt, Kerstin, Shih, le-Ming, Oba-Shinjo, Sueli Mieko, Siena, Salvatore, Theodorescu, Dan, Tie, Jeanne, Harkins, Timothy T., Veronese, Silvio, Wang, Tian-Li, Weingart, Jon D., Wolfgang, Christopher L., Wood, Laura D., Xing, Dongmei, Hruban, Ralph H., Wu, Jian, Allen, Peter J., Schmidt, C. Max, Choti, Michael A., Velculescu, Victor E., Kinzler, Kenneth W., Vogelstein, Bert, Papadopoulos, Nickolas, Diaz, Luis A.
Publicado em 2014