NTRK gene fusions as novel targets of cancer therapy across multiple tumour types

Por Amatu, Alessio, Sartore-Bianchi, Andrea, Siena, Salvatore
Publicado no ESMO Open (2016)

Aspirin for colorectal cancer with PIK3CA mutations: the rising of the oldest targeted therapy?

Por Amatu, Alessio, Bencardino, Katia, Sartore-Bianchi, Andrea, Siena, Salvatore
Publicado em 2013

Biomarkers Predicting Clinical Outcome of Epidermal Growth Factor Receptor–Targeted Therapy in Metastatic Colorectal Cancer

Por Siena, Salvatore, Sartore-Bianchi, Andrea, Di Nicolantonio, Federica, Balfour, Julia, Bardelli, Alberto
Publicado em 2009

Clonal evolution and KRAS-MET coamplification during secondary resistance to EGFR-targeted therapy in metastatic colorectal cancer

Por Sartore-Bianchi, Andrea, Valtorta, Emanuele, Amatu, Alessio, Veronese, Silvio, Lauricella, Calogero, Bonazzina, Erica, Siravegna, Giulia, Truini, Mauro, Bardelli, Alberto, Siena, Salvatore
Publicado no ESMO Open (2016)

Multi-Determinants Analysis of Molecular Alterations for Predicting Clinical Benefit to EGFR-Targeted Monoclonal Antibodies in Colorectal Cancer

Por Sartore-Bianchi, Andrea, Di Nicolantonio, Federica, Nichelatti, Michele, Molinari, Francesca, De Dosso, Sara, Saletti, Piercarlo, Martini, Miriam, Cipani, Tiziana, Marrapese, Giovanna, Mazzucchelli, Luca, Lamba, Simona, Veronese, Silvio, Frattini, Milo, Bardelli, Alberto, Siena, Salvatore
Publicado em 2009

Phase II Open-Label Study to Assess Efficacy and Safety of Lenalidomide in Combination with Cetuximab in KRAS-Mutant Metastatic Colorectal Cancer

Por Siena, Salvatore, Van Cutsem, Eric, Li, Mingyu, Jungnelius, Ulf, Romano, Alfredo, Beck, Robert, Bencardino, Katia, Elez, Maria Elena, Prenen, Hans, Sanchis, Mireia, Sartore-Bianchi, Andrea, Tejpar, Sabine, Gandhi, Anita, Shi, Tao, Tabernero, Josep
Publicado em 2013

Epigenetic Inactivation of the BRCA1 Interactor SRBC and Resistance to Oxaliplatin in Colorectal Cancer

Por Moutinho, Catia, Martinez-Cardús, Anna, Santos, Cristina, Navarro-Pérez, Valentin, Martínez-Balibrea, Eva, Musulen, Eva, Carmona, F. Javier, Sartore-Bianchi, Andrea, Cassingena, Andrea, Siena, Salvatore, Elez, Elena, Tabernero, Josep, Salazar, Ramon, Abad, Albert, Esteller, Manel
Publicado em 2013

Standardisation of EGFR FISH in colorectal cancer: results of an international interlaboratory reproducibility ring study

Por Sartore-Bianchi, Andrea, Fieuws, Steffen, Veronese, Silvio, Moroni, Mauro, Personeni, Nicola, Frattini, Milo, Torri, Valter, Cappuzzo, Federico, Borght, Sara Vander, Martin, Vittoria, Skokan, Margaret, Santoro, Armando, Gambacorta, Marcello, Tejpar, Sabine, Varella-Garcia, Marileila, Siena, Salvatore
Publicado no J Clin Pathol (2011)

Novel CAD-ALK gene rearrangement is drugable by entrectinib in colorectal cancer

Por Amatu, Alessio, Somaschini, Alessio, Cerea, Giulio, Bosotti, Roberta, Valtorta, Emanuele, Buonandi, Pasquale, Marrapese, Giovanna, Veronese, Silvio, Luo, David, Hornby, Zachary, Multani, Pratik, Murphy, Danielle, Shoemaker, Robert, Lauricella, Calogero, Giannetta, Laura, Maiolani, Martina, Vanzulli, Angelo, Ardini, Elena, Galvani, Arturo, Isacchi, Antonella, Sartore-Bianchi, Andrea, Siena, Salvatore
Publicado no Br J Cancer (2015)

Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer

Por Van Emburgh, Beth O., Arena, Sabrina, Siravegna, Giulia, Lazzari, Luca, Crisafulli, Giovanni, Corti, Giorgio, Mussolin, Benedetta, Baldi, Federica, Buscarino, Michela, Bartolini, Alice, Valtorta, Emanuele, Vidal, Joana, Bellosillo, Beatriz, Germano, Giovanni, Pietrantonio, Filippo, Ponzetti, Agostino, Albanell, Joan, Siena, Salvatore, Sartore-Bianchi, Andrea, Di Nicolantonio, Federica, Montagut, Clara, Bardelli, Alberto
Publicado no Nat Commun (2016)

Sensitivity to Entrectinib Associated With a Novel LMNA-NTRK1 Gene Fusion in Metastatic Colorectal Cancer

Por Sartore-Bianchi, Andrea, Ardini, Elena, Bosotti, Roberta, Amatu, Alessio, Valtorta, Emanuele, Somaschini, Alessio, Raddrizzani, Laura, Palmeri, Laura, Banfi, Patrizia, Bonazzina, Erica, Misale, Sandra, Marrapese, Giovanna, Leone, Antonella, Alzani, Rachele, Luo, David, Hornby, Zachary, Lim, Jonathan, Veronese, Silvio, Vanzulli, Angelo, Bardelli, Alberto, Martignoni, Marcella, Davite, Cristina, Galvani, Arturo, Isacchi, Antonella, Siena, Salvatore
Publicado no J Natl Cancer Inst (2015)

Prognostic significance of K-Ras mutation rate in metastatic colorectal cancer patients

Por Vincenzi, Bruno, Cremolini, Chiara, Sartore-Bianchi, Andrea, Russo, Antonio, Mannavola, Francesco, Perrone, Giuseppe, Pantano, Francesco, Loupakis, Fotios, Rossini, Daniele, Ongaro, Elena, Bonazzina, Erica, Dell'Aquila, Emanuela, Imperatori, Marco, Zoccoli, Alice, Bronte, Giuseppe, De Maglio, Giovanna, Fontanini, Gabriella, Natoli, Clara, Falcone, Alfredo, Santini, Daniele, Onetti-Muda, Andrea, Siena, Salvatore, Tonini, Giuseppe, Aprile, Giuseppe
Publicado no Oncotarget (2015)

Emergence of KRAS mutations and acquired resistance to anti EGFR therapy in colorectal cancer

Por Misale, Sandra, Yaeger, Rona, Hobor, Sebastijan, Scala, Elisa, Janakiraman, Manickam, Liska, David, Valtorta, Emanuele, Schiavo, Roberta, Buscarino, Michela, Siravegna, Giulia, Bencardino, Katia, Cercek, Andrea, Chen, Chin-Tung, Veronese, Silvio, Zanon, Carlo, Sartore-Bianchi, Andrea, Gambacorta, Marcello, Gallicchio, Margherita, Vakiani, Efsevia, Boscaro, Valentina, Medico, Enzo, Weiser, Martin, Siena, Salvatore, Di Nicolantonio, Federica, Solit, David, Bardelli, Alberto
Publicado em 2012

Tumor heterogeneity and lesion-specific response to targeted therapy in colorectal cancer

Por Russo, Mariangela, Siravegna, Giulia, Blaszkowsky, Lawrence S., Corti, Giorgio, Crisafulli, Giovanni, Ahronian, Leanne G., Mussolin, Benedetta, Kwak, Eunice L., Buscarino, Michela, Lazzari, Luca, Valtorta, Emanuele, Truini, Mauro, Jessop, Nicholas A., Robinson, Hayley E., Hong, Theodore S., Mino-Kenudson, Mari, Di Nicolantonio, Federica, Thabet, Ashraf, Sartore-Bianchi, Andrea, Siena, Salvatore, Iafrate, A. John, Bardelli, Alberto, Corcoran, Ryan B.
Publicado no Cancer Discov (2015)

Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer

Por Bardelli, Alberto, Corso, Simona, Bertotti, Andrea, Hobor, Sebastijan, Valtorta, Emanuele, Siravegna, Giulia, Sartore-Bianchi, Andrea, Scala, Elisa, Cassingena, Andrea, Zecchin, Davide, Apicella, Maria, Migliardi, Giorgia, Galimi, Francesco, Lauricella, Calogero, Zanon, Carlo, Perera, Timothy, Veronese, Silvio, Corti, Giorgio, Amatu, Alessio, Gambacorta, Marcello, Diaz, Luis A., Sausen, Mark, Velculescu, Victor E., Comoglio, Paolo, Trusolino, Livio, Di Nicolantonio, Federica, Giordano, Silvia, Siena, Salvatore
Publicado em 2013

Monitoring clonal evolution and resistance to EGFR blockade in the blood of metastatic colorectal cancer patients

Por Siravegna, Giulia, Mussolin, Benedetta, Buscarino, Michela, Corti, Giorgio, Cassingena, Andrea, Crisafulli, Giovanni, Ponzetti, Agostino, Cremolini, Chiara, Amatu, Alessio, Lauricella, Calogero, Lamba, Simona, Hobor, Sebastijan, Avallone, Antonio, Valtorta, Emanuele, Rospo, Giuseppe, Medico, Enzo, Motta, Valentina, Antoniotti, Carlotta, Tatangelo, Fabiana, Bellosillo, Beatriz, Veronese, Silvio, Budillon, Alfredo, Montagut, Clara, Racca, Patrizia, Marsoni, Silvia, Falcone, Alfredo, Corcoran, Ryan B., Di Nicolantonio, Federica, Loupakis, Fotios, Siena, Salvatore, Sartore-Bianchi, Andrea, Bardelli, Alberto
Publicado no Nat Med (2015)

Molecular landscape of acquired resistance to targeted therapy combinations in BRAF mutant colorectal cancer

Por Oddo, Daniele, Sennott, Erin M., Barault, Ludovic, Valtorta, Emanuele, Arena, Sabrina, Cassingena, Andrea, Filiciotto, Genny, Marzolla, Giulia, Elez, Elena, van Geel, Robin M.J.M., Bartolini, Alice, Crisafulli, Giovanni, Boscaro, Valentina, Godfrey, Jason T., Buscarino, Michela, Cancelliere, Carlotta, Linnebacher, Michael, Corti, Giorgio, Truini, Mauro, Siravegna, Giulia, Grasselli, Julieta, Gallicchio, Margherita, Bernards, René, Schellens, Jan H.M., Tabernero, Josep, Engelman, Jeffrey A., Sartore-Bianchi, Andrea, Bardelli, Alberto, Siena, Salvatore, Corcoran, Ryan B., Di Nicolantonio, Federica
Publicado no Cancer Res (2016)

The Genomic Landscape of Response to EGFR Blockade in Colorectal Cancer

Por Bertotti, Andrea, Papp, Eniko, Jones, Siân, Adleff, Vilmos, Anagnostou, Valsamo, Lupo, Barbara, Sausen, Mark, Phallen, Jillian, Hruban, Carolyn A., Tokheim, Collin, Niknafs, Noushin, Nesselbush, Monica, Lytle, Karli, Sassi, Francesco, Cottino, Francesca, Migliardi, Giorgia, Zanella, Eugenia R., Ribero, Dario, Russolillo, Nadia, Mellano, Alfredo, Muratore, Andrea, Paraluppi, Gianluca, Salizzoni, Mauro, Marsoni, Silvia, Kragh, Michael, Lantto, Johan, Cassingena, Andrea, Li, Qing Kay, Karchin, Rachel, Scharpf, Robert, Sartore-Bianchi, Andrea, Siena, Salvatore, Diaz, Luis A., Trusolino, Livio, Velculescu, Victor E.
Publicado no Nature (2015)

Safety and Antitumor Activity of the Multi-Targeted Pan-TRK, ROS1, and ALK Inhibitor Entrectinib (RXDX-101): Combined Results from Two Phase 1 Trials (ALKA-372-001 and STARTRK-1)

Por Drilon, Alexander, Siena, Salvatore, Ou, Sai-Hong Ignatius, Patel, Manish, Ahn, Myung Ju, Lee, Jeeyun, Bauer, Todd M., Farago, Anna F., Wheler, Jennifer J., Liu, Stephen V., Doebele, Robert, Giannetta, Laura, Cerea, Giulio, Marrapese, Giovanna, Schirru, Michele, Amatu, Alessio, Bencardino, Katia, Palmeri, Laura, Sartore-Bianchi, Andrea, Vanzulli, Angelo, Cresta, Sara, Damian, Silvia, Duca, Matteo, Ardini, Elena, Li, Gang, Christiansen, Jason, Kowalski, Karey, Johnson, Ann, Patel, Rupal, Luo, David, Chow-Maneval, Edna, Hornby, Zachary, Multani, Pratik S., Shaw, Alice T., De Braud, Filippo G.
Publicado no Cancer Discov (2017)

Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

Por Bettegowda, Chetan, Sausen, Mark, Leary, Rebecca J., Kinde, Isaac, Wang, Yuxuan, Agrawal, Nishant, Bartlett, Bjarne R., Wang, Hao, Luber, Brandon, Alani, Rhoda M., Antonarakis, Emmanuel S., Azad, Nilofer S., Bardelli, Alberto, Brem, Henry, Cameron, John L., Lee, Clarence C., Fecher, Leslie A., Gallia, Gary L., Gibbs, Peter, Le, Dung, Giuntoli, Robert L., Goggins, Michael, Hogarty, Michael D., Holdhoff, Matthias, Hong, Seung-Mo, Jiao, Yuchen, Juhl, Hartmut H., Kim, Jenny J., Siravegna, Giulia, Laheru, Daniel A., Lauricella, Calogero, Lim, Michael, Lipson, Evan J., Marie, Suely Kazue Nagahashi, Netto, George J., Oliner, Kelly S., Olivi, Alessandro, Olsson, Louise, Riggins, Gregory J., Sartore-Bianchi, Andrea, Schmidt, Kerstin, Shih, le-Ming, Oba-Shinjo, Sueli Mieko, Siena, Salvatore, Theodorescu, Dan, Tie, Jeanne, Harkins, Timothy T., Veronese, Silvio, Wang, Tian-Li, Weingart, Jon D., Wolfgang, Christopher L., Wood, Laura D., Xing, Dongmei, Hruban, Ralph H., Wu, Jian, Allen, Peter J., Schmidt, C. Max, Choti, Michael A., Velculescu, Victor E., Kinzler, Kenneth W., Vogelstein, Bert, Papadopoulos, Nickolas, Diaz, Luis A.
Publicado em 2014