Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer

EGFR targeted monoclonal antibodies are effective in a subset of metastatic colorectal tumors (mCRC). Inevitably, all patients develop resistance, which occurs through emergence of KRAS mutations in approximately 50% of the cases. We show that amplification of the MET proto-oncogene is associated wi...

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Detalhes bibliográficos
Main Authors: Bardelli, Alberto, Corso, Simona, Bertotti, Andrea, Hobor, Sebastijan, Valtorta, Emanuele, Siravegna, Giulia, Sartore-Bianchi, Andrea, Scala, Elisa, Cassingena, Andrea, Zecchin, Davide, Apicella, Maria, Migliardi, Giorgia, Galimi, Francesco, Lauricella, Calogero, Zanon, Carlo, Perera, Timothy, Veronese, Silvio, Corti, Giorgio, Amatu, Alessio, Gambacorta, Marcello, Diaz, Luis A., Sausen, Mark, Velculescu, Victor E., Comoglio, Paolo, Trusolino, Livio, Di Nicolantonio, Federica, Giordano, Silvia, Siena, Salvatore
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4078408/
https://ncbi.nlm.nih.gov/pubmed/23729478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-12-0558
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