Discovery of molecular determinants of response to targeted therapies in colorectal cancer using patient-derived xenografts (‘xenopatients’)

by Sassi, Francesco, Migliardi, Giorgia, Zanella, Eugenia, Galimi, Francesco, Cottino, Francesca, Bertotti, Andrea, Trusolino, Livio
Published 2013

Transfer of 4-hydroxynonenal, a inhibitory hemozoin (HZ) product, from HZ or HZ-laden phagocytes to developing human erythroid cells. A model for erythropoiesis inhibition in malar...

by Skorokhod, Oleksii A, Caione, Luisa, Migliardi, Giorgia, Barrera, Valentina, Piacibello, Wanda, Schwarzer, Evelin, Arese, Paolo
Published 2010

Epidermal Growth Factor Receptor (EGFR) mutation analysis, gene expression profiling and EGFR protein expression in primary prostate cancer

by Peraldo-Neia, Caterina, Migliardi, Giorgia, Mello-Grand, Maurizia, Montemurro, Filippo, Segir, Raffaella, Pignochino, Ymera, Cavalloni, Giuliana, Torchio, Bruno, Mosso, Luciano, Chiorino, Giovanna, Aglietta, Massimo
Published 2011

Targeting EGFR/HER2 pathways enhances the antiproliferative effect of gemcitabine in biliary tract and gallbladder carcinomas

by Pignochino, Ymera, Sarotto, Ivana, Peraldo-Neia, Caterina, Penachioni, Junia Y, Cavalloni, Giuliana, Migliardi, Giorgia, Casorzo, Laura, Chiorino, Giovanna, Risio, Mauro, Bardelli, Alberto, Aglietta, Massimo, Leone, Francesco
Published 2010

HER2 activating mutations are targets for colorectal cancer treatment

by Kavuri, Shyam M., Jain, Naveen, Galimi, Francesco, Cottino, Francesca, Leto, Simonetta M., Migliardi, Giorgia, Searleman, Adam C., Shen, Wei, Monsey, John, Trusolino, Livio, Jacobs, Samuel A., Bertotti, Andrea, Bose, Ron
Published in Cancer Discov (2015)

C-met inhibition blocks bone metastasis development induced by renal cancer stem cells

by D'Amico, Lucia, Belisario, Dimas, Migliardi, Giorgia, Grange, Cristina, Bussolati, Benedetta, D'Amelio, Patrizia, Perera, Timothy, Dalmasso, Ettore, Carbonare, Luca Dalle, Godio, Laura, Comoglio, Paolo, Trusolino, Livio, Ferracini, Riccardo, Roato, Ilaria
Published in Oncotarget (2016)

Combined blockade of MEK and PI3KCA as an effective antitumor strategy in HER2 gene amplified human colorectal cancer models

by Belli, Valentina, Matrone, Nunzia, Napolitano, Stefania, Migliardi, Giorgia, Cottino, Francesca, Bertotti, Andrea, Trusolino, Livio, Martinelli, Erika, Morgillo, Floriana, Ciardiello, Davide, De Falco, Vincenzo, Giunta, Emilio Francesco, Bracale, Umberto, Ciardiello, Fortunato, Troiani, Teresa
Published in J Exp Clin Cancer Res (2019)

Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-...

by Pignochino, Ymera, Grignani, Giovanni, Cavalloni, Giuliana, Motta, Manuela, Tapparo, Marta, Bruno, Stefania, Bottos, Alessia, Gammaitoni, Loretta, Migliardi, Giorgia, Camussi, Giovanni, Alberghini, Marco, Torchio, Bruno, Ferrari, Stefano, Bussolino, Federico, Fagioli, Franca, Picci, Piero, Aglietta, Massimo
Published 2009

Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer

by Bardelli, Alberto, Corso, Simona, Bertotti, Andrea, Hobor, Sebastijan, Valtorta, Emanuele, Siravegna, Giulia, Sartore-Bianchi, Andrea, Scala, Elisa, Cassingena, Andrea, Zecchin, Davide, Apicella, Maria, Migliardi, Giorgia, Galimi, Francesco, Lauricella, Calogero, Zanon, Carlo, Perera, Timothy, Veronese, Silvio, Corti, Giorgio, Amatu, Alessio, Gambacorta, Marcello, Diaz, Luis A., Sausen, Mark, Velculescu, Victor E., Comoglio, Paolo, Trusolino, Livio, Di Nicolantonio, Federica, Giordano, Silvia, Siena, Salvatore
Published 2013

Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell-like phenotype

by Lupo, Barbara, Sassi, Francesco, Pinnelli, Marika, Galimi, Francesco, Zanella, Eugenia R., Vurchio, Valentina, Migliardi, Giorgia, Gagliardi, Paolo Armando, Puliafito, Alberto, Manganaro, Daria, Luraghi, Paolo, Kragh, Michael, Pedersen, Mikkel W., Horak, Ivan D., Boccaccio, Carla, Medico, Enzo, Primo, Luca, Nichol, Daniel, Spiteri, Inmaculada, Heide, Timon, Vatsiou, Alexandra, Graham, Trevor A., Élez, Elena, Argiles, Guillem, Nuciforo, Paolo, Sottoriva, Andrea, Dienstmann, Rodrigo, Pasini, Diego, Grassi, Elena, Isella, Claudio, Bertotti, Andrea, Trusolino, Livio
Published in Sci Transl Med (2020)

The Genomic Landscape of Response to EGFR Blockade in Colorectal Cancer

by Bertotti, Andrea, Papp, Eniko, Jones, Siân, Adleff, Vilmos, Anagnostou, Valsamo, Lupo, Barbara, Sausen, Mark, Phallen, Jillian, Hruban, Carolyn A., Tokheim, Collin, Niknafs, Noushin, Nesselbush, Monica, Lytle, Karli, Sassi, Francesco, Cottino, Francesca, Migliardi, Giorgia, Zanella, Eugenia R., Ribero, Dario, Russolillo, Nadia, Mellano, Alfredo, Muratore, Andrea, Paraluppi, Gianluca, Salizzoni, Mauro, Marsoni, Silvia, Kragh, Michael, Lantto, Johan, Cassingena, Andrea, Li, Qing Kay, Karchin, Rachel, Scharpf, Robert, Sartore-Bianchi, Andrea, Siena, Salvatore, Diaz, Luis A., Trusolino, Livio, Velculescu, Victor E.
Published in Nature (2015)