Unveiling changes in the landscape of patient populations in cancer early drug development

Por Hierro, Cinta, Azaro, Analía, Argilés, Guillem, Elez, Elena, Gómez, Patricia, Carles, Joan, Rodon, Jordi
Publicado no Oncotarget (2016)

Epigenetic Inactivation of the BRCA1 Interactor SRBC and Resistance to Oxaliplatin in Colorectal Cancer

Por Moutinho, Catia, Martinez-Cardús, Anna, Santos, Cristina, Navarro-Pérez, Valentin, Martínez-Balibrea, Eva, Musulen, Eva, Carmona, F. Javier, Sartore-Bianchi, Andrea, Cassingena, Andrea, Siena, Salvatore, Elez, Elena, Tabernero, Josep, Salazar, Ramon, Abad, Albert, Esteller, Manel
Publicado em 2013

Phase Ib/II, open-label, dose-escalation study of LGX818, an oral selective BRAF inhibitor, in combination with MEK162, an oral MEK1/2 inhibitor, in patients with BRAF V600-depende...

Por Kefford, Richard, Sullivan, Ryan J, Miller, Wilson H, Elez, Elena M, Tan, Daniel, Kim, Kevin B, Long, Georgina V, Flaherty, Keith T, Tai, David, Stutvoet, Simone, Maacke, Heiko, Whiley, Matt, Parseval, Laure Moutouh-de, Tabernero, Josep
Publicado em 2014

Randomized Phase Ib/II Trial of Rilotumumab or Ganitumab with Panitumumab versus Panitumumab Alone in Patients with Wild-type KRAS Metastatic Colorectal Cancer

Por Cutsem, Eric Van, Eng, Cathy, Nowara, Elzbieta, Świeboda-Sadlej, Anna, Tebbutt, Niall C., Mitchell, Edith, Davidenko, Irina, Stephenson, Joe, Elez, Elena, Prenen, Hans, Deng, Hongjie, Tang, Rui, McCaffery, Ian, Oliner, Kelly S., Chen, Lisa, Gansert, Jennifer, Loh, Elwyn, Smethurst, Dominic, Tabernero, Josep
Publicado no Clin Cancer Res (2014)

Analysis of mutant allele fractions in driver genes in colorectal cancer – biological and clinical insights

Por Dienstmann, Rodrigo, Elez, Elena, Argiles, Guillem, Matos, Ignacio, Sanz‐Garcia, Enrique, Ortiz, Carolina, Macarulla, Teresa, Capdevila, Jaume, Alsina, Maria, Sauri, Tamara, Verdaguer, Helena, Vilaro, Marta, Ruiz‐Pace, Fiorella, Viaplana, Cristina, Garcia, Ariadna, Landolfi, Stefania, Palmer, Hector G., Nuciforo, Paolo, Rodon, Jordi, Vivancos, Ana, Tabernero, Josep
Publicado no Mol Oncol (2017)

Safety and antitumor activity of the anti–PD-1 antibody pembrolizumab in patients with advanced colorectal carcinoma

Por O’Neil, Bert H., Wallmark, John M., Lorente, David, Elez, Elena, Raimbourg, Judith, Gomez-Roca, Carlos, Ejadi, Samuel, Piha-Paul, Sarina A., Stein, Mark N., Abdul Razak, Albiruni R., Dotti, Katia, Santoro, Armando, Cohen, Roger B., Gould, Marlena, Saraf, Sanatan, Stein, Karen, Han, Sae-Won
Publicado no PLoS One (2017)

ICECREAM: randomised phase II study of cetuximab alone or in combination with irinotecan in patients with metastatic colorectal cancer with either KRAS, NRAS, BRAF and PI3KCA wild...

Por Segelov, Eva, Waring, Paul, Desai, Jayesh, Wilson, Kate, Gebski, Val, Thavaneswaran, Subotheni, Elez, Elena, Underhill, Craig, Pavlakis, Nick, Chantrill, Lorraine, Nott, Louise, Jefford, Michael, Khasraw, Mustafa, Day, Fiona, Wasan, Harpreet, Ciardiello, Fortunato, Karapetis, Chris, Joubert, Warren, van Hazel, Guy, Haydon, Andrew, Price, Tim, Tejpar, Sabine, Tebbutt, Niall, Shapiro, Jeremy
Publicado no BMC Cancer (2016)

Vemurafenib for BRAF V600–Mutant Erdheim-Chester Disease and Langerhans Cell Histiocytosis: Analysis of Data From the Histology-Independent, Phase 2, Open-label VE-BASKET Study

Por Diamond, Eli L., Subbiah, Vivek, Lockhart, A. Craig, Blay, Jean-Yves, Puzanov, Igor, Chau, Ian, Raje, Noopur S., Wolf, Jurgen, Erinjeri, Joseph P., Torrisi, Jean, Lacouture, Mario, Elez, Elena, Martínez-Valle, Ferran, Durham, Benjamin, Arcila, Maria E., Ulaner, Gary, Abdel-Wahab, Omar, Pitcher, Bethany, Makrutzki, Martina, Riehl, Todd, Baselga, José, Hyman, David M.
Publicado no JAMA Oncol (2017)

A Phase 1b Dose-Escalation Study of Encorafenib (LGX818) and Cetuximab With or Without Alpelisib in Metastatic BRAF-Mutant Colorectal Cancer

Por van Geel, Robin M.J.M., Tabernero, Josep, Elez, Elena, Bendell, Johanna C., Spreafico, Anna, Schuler, Martin, Yoshino, Takayuki, Delord, Jean-Pierre, Yamada, Yasuhide, Lolkema, Martijn P., Faris, Jason E., Eskens, Ferry A.L.M., Sharma, Sunil, Yaeger, Rona, Lenz, Heinz-Josef, Wainberg, Zev A., Avsar, Emin, Chatterjee, Arkendu, Jaeger, Savina, Tan, Eugene, Maharry, Kati, Demuth, Tim, Schellens, Jan H.M.
Publicado no Cancer Discov (2017)

Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer

Por Bullman, Susan, Pedamallu, Chandra S., Sicinska, Ewa, Clancy, Thomas E., Zhang, Xiaoyang, Cai, Diana, Neuberg, Donna, Huang, Katherine, Guevara, Fatima, Nelson, Timothy, Chipashvili, Otari, Hagan, Timothy, Walker, Mark, Ramachandran, Aruna, Diosdado, Begoña, Serna, Garazi, Mulet, Nuria, Landolfi, Stefania, Cajal, Santiago Ramon y, Fasani, Roberta, Aguirre, Andrew J., Ng, Kimmie, Élez, Elena, Ogino, Shuji, Tabernero, Josep, Fuchs, Charles S., Hahn, William C., Nuciforo, Paolo, Meyerson, Matthew
Publicado no Science (2017)

Epigenetic activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting EGFR

Por Vizoso, Miguel, Ferreira, Humberto J, Lopez-Serra, Paula, Javier Carmona, F, Martínez-Cardús, Anna, Girotti, Maria Romina, Villanueva, Alberto, Guil, Sonia, Moutinho, Catia, Liz, Julia, Portela, Anna, Heyn, Holger, Moran, Sebastian, Vidal, August, Martinez-Iniesta, Maria, Manzano, Jose L, Fernandez-Figueras, Maria Teresa, Elez, Elena, Muñoz-Couselo, Eva, Botella-Estrada, Rafael, Berrocal, Alfonso, Pontén, Fredrik, van den Oord, Joost, Gallagher, William M, Frederick, Dennie T, Flaherty, Keith T, McDermott, Ultan, Lorigan, Paul, Marais, Richard, Esteller, Manel
Publicado no Nat Med (2015)

Molecular landscape of acquired resistance to targeted therapy combinations in BRAF mutant colorectal cancer

Por Oddo, Daniele, Sennott, Erin M., Barault, Ludovic, Valtorta, Emanuele, Arena, Sabrina, Cassingena, Andrea, Filiciotto, Genny, Marzolla, Giulia, Elez, Elena, van Geel, Robin M.J.M., Bartolini, Alice, Crisafulli, Giovanni, Boscaro, Valentina, Godfrey, Jason T., Buscarino, Michela, Cancelliere, Carlotta, Linnebacher, Michael, Corti, Giorgio, Truini, Mauro, Siravegna, Giulia, Grasselli, Julieta, Gallicchio, Margherita, Bernards, René, Schellens, Jan H.M., Tabernero, Josep, Engelman, Jeffrey A., Sartore-Bianchi, Andrea, Bardelli, Alberto, Siena, Salvatore, Corcoran, Ryan B., Di Nicolantonio, Federica
Publicado no Cancer Res (2016)