FOLFIRI Plus Bevacizumab 5 mg/kg Versus 10 mg/kg as Second-line Therapy in Patients with Metastatic Colorectal Cancer Who Have Failed First-line Bevacizumab Plus Oxaliplatin-based...

Por Mishima, Hideyuki, Oba, Koji, Sakamoto, Junichi, Muro, Kei, Yoshino, Takayuki, Hyodo, Ichinosuke, Maehara, Yoshihiko
Publicado em 2012

Phase 1 study of trebananib (AMG 386), an angiogenesis targeting angiopoietin-1/2 antagonist, in Japanese patients with advanced solid tumors

Por Doi, Toshihiko, Ohtsu, Atsushi, Fuse, Nozomu, Yoshino, Takayuki, Tahara, Makoto, Shibayama, Kazuhiro, Takubo, Takatoshi, Weinreich, David M.
Publicado em 2012

Phase I study of TAS-102 and irinotecan combination therapy in Japanese patients with advanced colorectal cancer

Por Doi, Toshihiko, Yoshino, Takayuki, Fuse, Nozomu, Boku, Narikazu, Yamazaki, Kentaro, Koizumi, Wasaburo, Shimada, Ken, Takinishi, Yasutaka, Ohtsu, Atsushi
Publicado no Invest New Drugs (2015)

Concordance between PIK3CA mutations in endoscopic biopsy and surgically resected specimens of esophageal squamous cell carcinoma

Por Hatogai, Ken, Fujii, Satoshi, Kojima, Takashi, Daiko, Hiroyuki, Doi, Toshihiko, Ohtsu, Atsushi, Ochiai, Atsushi, Takiguchi, Yuichi, Yoshino, Takayuki
Publicado no BMC Cancer (2017)

A Phase I study of intravenous PI3K inhibitor copanlisib in Japanese patients with advanced or refractory solid tumors

Por Doi, Toshihiko, Fuse, Nozomu, Yoshino, Takayuki, Kojima, Takashi, Bando, Hideaki, Miyamoto, Hideaki, Kaneko, Masato, Osada, Motonobu, Ohtsu, Atsushi
Publicado no Cancer Chemother Pharmacol (2016)

Incidence and localization of lymphoid follicles in early colorectal neoplasms

Por Fu, Kuang-I, Sano, Yasushi, Kato, Shigeharu, Fujii, Takahiro, Koba, Ikuro, Yoshino, Takayuki, Ochiai, Atsushi, Yoshida, Shigeaki, Fujimori, Takahiro
Publicado no World J Gastroenterol (2005)

A phase I study of intravenous aflibercept with FOLFIRI in Japanese patients with previously treated metastatic colorectal cancer

Por Yoshino, Takayuki, Yamazaki, Kentaro, Yamaguchi, Kensei, Doi, Toshihiko, Boku, Narikazu, Machida, Nozomu, Onozawa, Yusuke, Asayama, Masako, Fujino, Tadahiro, Ohtsu, Atsushi
Publicado em 2012

Phase 1 study of efatutazone, a novel oral peroxisome proliferator-activated receptor gamma agonist, in combination with FOLFIRI as second-line therapy in patients with metastatic...

Por Komatsu, Yoshito, Yoshino, Takayuki, Yamazaki, Kentaro, Yuki, Satoshi, Machida, Nozomu, Sasaki, Takahide, Hyodo, Ichinosuke, Yachi, Yutaka, Onuma, Hiroshi, Ohtsu, Atsushi
Publicado em 2013

Phase I dose-escalation study of the HSP90 inhibitor AUY922 in Japanese patients with advanced solid tumors

Por Doi, Toshihiko, Onozawa, Yusuke, Fuse, Nozomu, Yoshino, Takayuki, Yamazaki, Kentaro, Watanabe, Junichiro, Akimov, Mikhail, Robson, Matthew, Boku, Narikazu, Ohtsu, Atsushi
Publicado em 2014

Japanese Society of Medical Oncology Clinical Guidelines: RAS (KRAS/NRAS) mutation testing in colorectal cancer patients11

Por Taniguchi, Hiroya, Yamazaki, Kentaro, Yoshino, Takayuki, Muro, Kei, Yatabe, Yasushi, Watanabe, Toshiaki, Ebi, Hiromichi, Ochiai, Atsushi, Baba, Eishi, Tsuchihara, Katsuya
Publicado no Cancer Sci (2015)

Chemotherapy induced neutropenia at 1-month mark is a predictor of overall survival in patients receiving TAS-102 for refractory metastatic colorectal cancer: a cohort study

Por Kasi, Pashtoon M., Kotani, Daisuke, Cecchini, Michael, Shitara, Kohei, Ohtsu, Atsushi, Ramanathan, Ramesh K., Hochster, Howard S., Grothey, Axel, Yoshino, Takayuki
Publicado no BMC Cancer (2016)

Clinical outcomes of patients with gastrointestinal stromal tumor in phase I clinical trials

Por Nagatani, Yoshiaki, Shitara, Kohei, Bando, Hideaki, Kuboki, Yasutoshi, Okamoto, Wataru, Kojima, Takashi, Yoshino, Takayuki, Nishida, Toshirou, Ohtsu, Atushi, Doi, Toshihiko
Publicado no BMC Cancer (2016)

Feasibility of classical secondary hormonal therapies prior to docetaxel therapy in Japanese patients with castration-resistant prostate cancer: Multicenter retrospective study

Por Kandori, Shuya, Yoshino, Takayuki, Tsutsumi, Masakazu, Yamauchi, Atsushi, Ohtani, Mikinobu, Fukuhara, Yoshiharu, Miyanaga, Naoto, Miyazaki, Jun, Nishiyama, Hiroyuki, Shimazui, Toru
Publicado no Prostate Int (2016)

Phase 1 pharmacokinetic study of MK-0646 (dalotuzumab), an anti-insulin-like growth factor-1 receptor monoclonal antibody, in combination with cetuximab and irinotecan in Japanese...

Por Doi, Toshihiko, Muro, Kei, Yoshino, Takayuki, Fuse, Nozomu, Ura, Takashi, Takahari, Daisuke, Feng, Hwa-ping, Shimamoto, Takashi, Noguchi, Kazuo, Ohtsu, Atsushi
Publicado em 2013

5-Fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) plus sunitinib or bevacizumab as first-line treatment for metastatic colorectal cancer: a randomized Phase IIb study

Por Hecht, J Randolph, Mitchell, Edith P, Yoshino, Takayuki, Welslau, Manfred, Lin, Xun, Chow Maneval, Edna, Paolini, Jolanda, Lechuga, Maria Jose, Kretzschmar, Albrecht
Publicado no Cancer Manag Res (2015)

Phase 1 pharmacokinetic study of the oral pan-AKT inhibitor MK-2206 in Japanese patients with advanced solid tumors

Por Doi, Toshihiko, Tamura, Kenji, Tanabe, Yuko, Yonemori, Kan, Yoshino, Takayuki, Fuse, Nozomu, Kodaira, Makoto, Bando, Hideaki, Noguchi, Kazuo, Shimamoto, Takashi, Ohtsu, Atsushi
Publicado no Cancer Chemother Pharmacol (2015)

Effect of food on the pharmacokinetics of TAS‐102 and its efficacy and safety in patients with advanced solid tumors

Por Yoshino, Takayuki, Kojima, Takashi, Bando, Hideaki, Yamazaki, Tomoko, Naito, Yoichi, Mukai, Hirofumi, Fuse, Nozomu, Goto, Koichi, Ito, Yuko, Doi, Toshihiko, Ohtsu, Atsushi
Publicado no Cancer Sci (2016)

Comprehensive immunohistochemical analysis of tumor microenvironment immune status in esophageal squamous cell carcinoma

Por Hatogai, Ken, Kitano, Shigehisa, Fujii, Satoshi, Kojima, Takashi, Daiko, Hiroyuki, Nomura, Shogo, Yoshino, Takayuki, Ohtsu, Atsushi, Takiguchi, Yuichi, Doi, Toshihiko, Ochiai, Atsushi
Publicado no Oncotarget (2016)

Phase I dose-escalation study of buparlisib (BKM120), an oral pan-class I PI3K inhibitor, in Japanese patients with advanced solid tumors

Por Ando, Yuichi, Inada-Inoue, Megumi, Mitsuma, Ayako, Yoshino, Takayuki, Ohtsu, Atsushi, Suenaga, Naoko, Sato, Masahiko, Kakizume, Tomoyuki, Robson, Matthew, Quadt, Cornelia, Doi, Toshihiko
Publicado no Cancer Sci (2014)

Phase 1 study of ganitumab (AMG 479), a fully human monoclonal antibody against the insulin-like growth factor receptor type I (IGF1R), in Japanese patients with advanced solid tum...

Por Murakami, Haruyasu, Doi, Toshihiko, Yamamoto, Nobuyuki, Watanabe, Junichiro, Boku, Narikazu, Fuse, Nozomu, Yoshino, Takayuki, Ohtsu, Atsushi, Otani, Satoru, Shibayama, Kazuhiro, Takubo, Takatoshi, Loh, Elwyn
Publicado em 2012