Phase I dose-escalation study of the HSP90 inhibitor AUY922 in Japanese patients with advanced solid tumors

PURPOSE: AUY922 is a potent non-geldanamycin inhibitor of heat-shock protein 90. This study was carried out in Japanese patients to determine the maximum tolerated dose (MTD), and to characterize safety, tolerability and pharmacokinetics of single-agent AUY922. METHODS: Japanese patients with advanc...

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Hlavní autoři: Doi, Toshihiko, Onozawa, Yusuke, Fuse, Nozomu, Yoshino, Takayuki, Yamazaki, Kentaro, Watanabe, Junichiro, Akimov, Mikhail, Robson, Matthew, Boku, Narikazu, Ohtsu, Atsushi
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2014
Témata:
Clinical Trial Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4143601/
https://ncbi.nlm.nih.gov/pubmed/25059319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-014-2521-x
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