Immunotherapy for Esophageal Squamous Cell Carcinoma

Por Kojima, Takashi, Doi, Toshihiko
Publicado no Curr Oncol Rep (2017)

A Phase Ib Study of Safety and Pharmacokinetics of Ramucirumab in Combination With Paclitaxel in Patients With Advanced Gastric Adenocarcinomas

Por Ueda, Shinya, Satoh, Taroh, Gotoh, Masahiro, Gao, Ling, Doi, Toshihiko
Publicado no Oncologist (2015)

Phase I study of olaratumab in Japanese patients with advanced solid tumors

Por Doi, Toshihiko, Ma, Yan, Dontabhaktuni, Aruna, Nippgen, Cornelia, Nippgen, Johannes, Ohtsu, Atsushi
Publicado no Cancer Sci (2014)

Phase I Clinical and Pharmacokinetic Study of RAD001 (Everolimus) Administered Daily to Japanese Patients with Advanced Solid Tumors

Por Okamoto, Isamu, Doi, Toshihiko, Ohtsu, Atsushi, Miyazaki, Masaki, Tsuya, Asuka, Kurei, Katsutoshi, Kobayashi, Ken, Nakagawa, Kazuhiko
Publicado em 2010

Phase 1 study of trebananib (AMG 386), an angiogenesis targeting angiopoietin-1/2 antagonist, in Japanese patients with advanced solid tumors

Por Doi, Toshihiko, Ohtsu, Atsushi, Fuse, Nozomu, Yoshino, Takayuki, Tahara, Makoto, Shibayama, Kazuhiro, Takubo, Takatoshi, Weinreich, David M.
Publicado em 2012

Regorafenib for advanced gastrointestinal stromal tumors following imatinib and sunitinib treatment: a subgroup analysis evaluating Japanese patients in the phase III GRID trial

Por Komatsu, Yoshito, Doi, Toshihiko, Sawaki, Akira, Kanda, Tatsuo, Yamada, Yasuhide, Kuss, Iris, Demetri, George D, Nishida, Toshirou
Publicado no Int J Clin Oncol (2015)

Phase I study of TAS-102 and irinotecan combination therapy in Japanese patients with advanced colorectal cancer

Por Doi, Toshihiko, Yoshino, Takayuki, Fuse, Nozomu, Boku, Narikazu, Yamazaki, Kentaro, Koizumi, Wasaburo, Shimada, Ken, Takinishi, Yasutaka, Ohtsu, Atsushi
Publicado no Invest New Drugs (2015)

Concordance between PIK3CA mutations in endoscopic biopsy and surgically resected specimens of esophageal squamous cell carcinoma

Por Hatogai, Ken, Fujii, Satoshi, Kojima, Takashi, Daiko, Hiroyuki, Doi, Toshihiko, Ohtsu, Atsushi, Ochiai, Atsushi, Takiguchi, Yuichi, Yoshino, Takayuki
Publicado no BMC Cancer (2017)

A Phase I study of intravenous PI3K inhibitor copanlisib in Japanese patients with advanced or refractory solid tumors

Por Doi, Toshihiko, Fuse, Nozomu, Yoshino, Takayuki, Kojima, Takashi, Bando, Hideaki, Miyamoto, Hideaki, Kaneko, Masato, Osada, Motonobu, Ohtsu, Atsushi
Publicado no Cancer Chemother Pharmacol (2016)

A phase I study of intravenous aflibercept with FOLFIRI in Japanese patients with previously treated metastatic colorectal cancer

Por Yoshino, Takayuki, Yamazaki, Kentaro, Yamaguchi, Kensei, Doi, Toshihiko, Boku, Narikazu, Machida, Nozomu, Onozawa, Yusuke, Asayama, Masako, Fujino, Tadahiro, Ohtsu, Atsushi
Publicado em 2012

Phase I dose-escalation study of the HSP90 inhibitor AUY922 in Japanese patients with advanced solid tumors

Por Doi, Toshihiko, Onozawa, Yusuke, Fuse, Nozomu, Yoshino, Takayuki, Yamazaki, Kentaro, Watanabe, Junichiro, Akimov, Mikhail, Robson, Matthew, Boku, Narikazu, Ohtsu, Atsushi
Publicado em 2014

Clinical outcomes of patients with gastrointestinal stromal tumor in phase I clinical trials

Por Nagatani, Yoshiaki, Shitara, Kohei, Bando, Hideaki, Kuboki, Yasutoshi, Okamoto, Wataru, Kojima, Takashi, Yoshino, Takayuki, Nishida, Toshirou, Ohtsu, Atushi, Doi, Toshihiko
Publicado no BMC Cancer (2016)

NC-6004 Phase I study in combination with gemcitabine for advanced solid tumors and population PK/PD analysis

Por Doi, Toshihiko, Hamaguchi, Tetsuya, Shitara, Kohei, Iwasa, Satoru, Shimada, Yasuhiro, Harada, Mitsunori, Naito, Kenichiro, Hayashi, Naoto, Masada, Atsuhiro, Ohtsu, Atsushi
Publicado no Cancer Chemother Pharmacol (2017)

Phase II study of motesanib in Japanese patients with advanced gastrointestinal stromal tumors with prior exposure to imatinib mesylate

Por Sawaki, Akira, Yamada, Yasuhide, Komatsu, Yoshito, Kanda, Tatsuo, Doi, Toshihiko, Koseki, Masato, Baba, Hideo, Sun, Yu-Nien, Murakami, Koji, Nishida, Toshirou
Publicado em 2009

Phase 1 pharmacokinetic study of MK-0646 (dalotuzumab), an anti-insulin-like growth factor-1 receptor monoclonal antibody, in combination with cetuximab and irinotecan in Japanese...

Por Doi, Toshihiko, Muro, Kei, Yoshino, Takayuki, Fuse, Nozomu, Ura, Takashi, Takahari, Daisuke, Feng, Hwa-ping, Shimamoto, Takashi, Noguchi, Kazuo, Ohtsu, Atsushi
Publicado em 2013

Phase I/II Study of Capecitabine Plus Oxaliplatin (XELOX) Plus Bevacizumab As First-line Therapy in Japanese Patients with Metastatic Colorectal Cancer

Por Doi, Toshihiko, Boku, Narikazu, Kato, Ken, Komatsu, Yoshito, Yamaguchi, Kensei, Muro, Kei, Hamamoto, Yasuo, Sato, Atsushi, Koizumi, Wasaburo, Mizunuma, Nobuyuki, Takiuchi, Hiroya
Publicado em 2010

Phase 1 pharmacokinetic study of the oral pan-AKT inhibitor MK-2206 in Japanese patients with advanced solid tumors

Por Doi, Toshihiko, Tamura, Kenji, Tanabe, Yuko, Yonemori, Kan, Yoshino, Takayuki, Fuse, Nozomu, Kodaira, Makoto, Bando, Hideaki, Noguchi, Kazuo, Shimamoto, Takashi, Ohtsu, Atsushi
Publicado no Cancer Chemother Pharmacol (2015)

Phase I Study of Axitinib in Combination with Cisplatin and Capecitabine in Patients with Previously Untreated Advanced Gastric Cancer

Por Oh, Do-Youn, Doi, Toshihiko, Shirao, Kuniaki, Lee, Keun-Wook, Park, Sook Ryun, Chen, Ying, Yang, Liqiang, Valota, Olga, Bang, Yung-Jue
Publicado no Cancer Res Treat (2015)

Local efficacy and survival outcome of salvage endoscopic therapy for local recurrent lesions after definitive chemoradiotherapy for esophageal cancer

Por Hatogai, Ken, Yano, Tomonori, Kojima, Takashi, Onozawa, Masakatsu, Fujii, Satoshi, Daiko, Hiroyuki, Yoda, Yusuke, Hombu, Takuya, Doi, Toshihiko, Kaneko, Kazuhiro, Ohtsu, Atsushi
Publicado no Radiat Oncol (2016)

Effect of food on the pharmacokinetics of TAS‐102 and its efficacy and safety in patients with advanced solid tumors

Por Yoshino, Takayuki, Kojima, Takashi, Bando, Hideaki, Yamazaki, Tomoko, Naito, Yoichi, Mukai, Hirofumi, Fuse, Nozomu, Goto, Koichi, Ito, Yuko, Doi, Toshihiko, Ohtsu, Atsushi
Publicado no Cancer Sci (2016)