Phase I Clinical and Pharmacokinetic Study of RAD001 (Everolimus) Administered Daily to Japanese Patients with Advanced Solid Tumors

OBJECTIVE: To determine the pharmacokinetics and safety of RAD001 (everolimus) in Japanese patients with advanced solid tumors. METHODS: An open-label, non-randomized, dose-escalation Phase I study of RAD001 administered continuously once daily in a 28-day cycle was performed. The study had a ‘3 + 3...

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Bibliographische Detailangaben
Hauptverfasser: Okamoto, Isamu, Doi, Toshihiko, Ohtsu, Atsushi, Miyazaki, Masaki, Tsuya, Asuka, Kurei, Katsutoshi, Kobayashi, Ken, Nakagawa, Kazuhiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2010
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2800315/
https://ncbi.nlm.nih.gov/pubmed/19783551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jjco/hyp120
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