EVEROLIMUS (RAD001) AND THE MTOR PATHWAY IN LOW-GRADE GLIOMAS

BACKGROUND: Low-grade gliomas (LGG) are slow growing, primary brain tumors that frequently recur after primary surgical treatment. Recent work has suggested the activation of the PI3K/mTOR pathway in >50% of LGG, raising the possibility that treatment with mTOR inhibitors such as everolimus (RAD0...

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Hlavní autoři: Clarke, Jennifer L., Chang, Susan, Phillips, Joanna, Molinaro, Annette, Berger, Mitchel, Nelson, Sarah, Haas-Kogan, Daphne
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144638/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou209.24
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