Probing the PI3K/mTOR Pathway in Gliomas: A Phase II Study of Everolimus for Recurrent Adult Low Grade Gliomas

BACKGROUND: Activation of the PI3K/mTOR pathway is common in patients with low-grade gliomas (LGG), but agents that inhibit this pathway, including mTOR inhibitors, have not been studied in this population. METHODS: 58 patients with pathologic evidence of recurrence after initially diagnosed WHO gra...

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Detalhes bibliográficos
Publicado no:Cancer
Main Authors: Wahl, Michael, Chang, Susan M., Phillips, Joanna J., Molinaro, Annette M., Costello, Joseph F., Mazor, Tali, Alexandrescu, Sanda, Lupo, Janine M., Nelson, Sarah J., Berger, Mitchel, Prados, Michael, Taylor, Jennie W., Butowski, Nicholas, Clarke, Jennifer L., Haas-Kogan, Daphne
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693663/
https://ncbi.nlm.nih.gov/pubmed/28759109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.30909
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