Probing the PI3K/mTOR Pathway in Gliomas: A Phase II Study of Everolimus for Recurrent Adult Low Grade Gliomas

BACKGROUND: Activation of the PI3K/mTOR pathway is common in patients with low-grade gliomas (LGG), but agents that inhibit this pathway, including mTOR inhibitors, have not been studied in this population. METHODS: 58 patients with pathologic evidence of recurrence after initially diagnosed WHO gra...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cancer
Auteurs principaux: Wahl, Michael, Chang, Susan M., Phillips, Joanna J., Molinaro, Annette M., Costello, Joseph F., Mazor, Tali, Alexandrescu, Sanda, Lupo, Janine M., Nelson, Sarah J., Berger, Mitchel, Prados, Michael, Taylor, Jennie W., Butowski, Nicholas, Clarke, Jennifer L., Haas-Kogan, Daphne
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693663/
https://ncbi.nlm.nih.gov/pubmed/28759109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.30909
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