Probing the PI3K/mTOR Pathway in Gliomas: A Phase II Study of Everolimus for Recurrent Adult Low Grade Gliomas

BACKGROUND: Activation of the PI3K/mTOR pathway is common in patients with low-grade gliomas (LGG), but agents that inhibit this pathway, including mTOR inhibitors, have not been studied in this population. METHODS: 58 patients with pathologic evidence of recurrence after initially diagnosed WHO gra...

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Publicat a:Cancer
Autors principals: Wahl, Michael, Chang, Susan M., Phillips, Joanna J., Molinaro, Annette M., Costello, Joseph F., Mazor, Tali, Alexandrescu, Sanda, Lupo, Janine M., Nelson, Sarah J., Berger, Mitchel, Prados, Michael, Taylor, Jennie W., Butowski, Nicholas, Clarke, Jennifer L., Haas-Kogan, Daphne
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693663/
https://ncbi.nlm.nih.gov/pubmed/28759109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.30909
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