NC-6004 Phase I study in combination with gemcitabine for advanced solid tumors and population PK/PD analysis

OBJECTIVES: This study was an open-label phase I study to confirm the safety and tolerability of NC-6004 in combination with gemcitabine in Japanese patients with advanced solid tumors and to assess the PK effects of NC-6004 monotherapy. METHODS: This phase I study used a 3 + 3 design to determine t...

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Publicat a:Cancer Chemother Pharmacol
Autors principals: Doi, Toshihiko, Hamaguchi, Tetsuya, Shitara, Kohei, Iwasa, Satoru, Shimada, Yasuhiro, Harada, Mitsunori, Naito, Kenichiro, Hayashi, Naoto, Masada, Atsuhiro, Ohtsu, Atsushi
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2017
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344954/
https://ncbi.nlm.nih.gov/pubmed/28224231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-017-3254-4
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