Biomarkers Predicting Clinical Outcome of Epidermal Growth Factor Receptor–Targeted Therapy in Metastatic Colorectal Cancer

Por Siena, Salvatore, Sartore-Bianchi, Andrea, Di Nicolantonio, Federica, Balfour, Julia, Bardelli, Alberto
Publicado em 2009

The cholesterol biosynthesis enzyme oxidosqualene cyclase is a new target to impair tumour angiogenesis and metastasis dissemination

Por Maione, Federica, Oliaro-Bosso, Simonetta, Meda, Claudia, Di Nicolantonio, Federica, Bussolino, Federico, Balliano, Gianni, Viola, Franca, Giraudo, Enrico
Publicado no Sci Rep (2015)

The in vitro effect of gefitinib ('Iressa') alone and in combination with cytotoxic chemotherapy on human solid tumours

Por Knight, Louise A, Di Nicolantonio, Federica, Whitehouse, Pauline, Mercer, Stuart, Sharma, Sanjay, Glaysher, Sharon, Johnson, Penny, Cree, Ian A
Publicado em 2004

Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia

Por Bottos, Alessia, Martini, Miriam, Di Nicolantonio, Federica, Comunanza, Valentina, Maione, Federica, Minassi, Alberto, Appendino, Giovanni, Bussolino, Federico, Bardelli, Alberto
Publicado em 2012

Prognostic significance of cyclooxygenase-2 (COX-2) expression in patients with surgically resectable adenocarcinoma of the oesophagus

Por Bhandari, Pradeep, Bateman, Adrian C, Mehta, Raj L, Stacey, Bernard SF, Johnson, Penny, Cree, Ian A, Di Nicolantonio, Federica, Patel, Praful
Publicado em 2006

VEGF blockade enhances the antitumor effect of BRAF(V) (600E) inhibition

Por Comunanza, Valentina, Corà, Davide, Orso, Francesca, Consonni, Francesca Maria, Middonti, Emanuele, Di Nicolantonio, Federica, Buzdin, Anton, Sica, Antonio, Medico, Enzo, Sangiolo, Dario, Taverna, Daniela, Bussolino, Federico
Publicado no EMBO Mol Med (2016)

Outcome of ATP-based tumor chemosensitivity assay directed chemotherapy in heavily pre-treated recurrent ovarian carcinoma

Por Sharma, Sanjay, Neale, Michael H, Di Nicolantonio, Federica, Knight, Louise A, Whitehouse, Pauline A, Mercer, Stuart J, Higgins, Bernard R, Lamont, Alan, Osborne, Richard, Hindley, Andrew C, Kurbacher, Christian M, Cree, Ian A
Publicado em 2003

Replacement of normal with mutant alleles in the genome of normal human cells unveils mutation-specific drug responses

Por Di Nicolantonio, Federica, Arena, Sabrina, Gallicchio, Margherita, Zecchin, Davide, Martini, Miriam, Flonta, Simona Emilia, Stella, Giulia Maria, Lamba, Simona, Cancelliere, Carlotta, Russo, Mariangela, Geuna, Massimo, Appendino, Giovanni, Fantozzi, Roberto, Medico, Enzo, Bardelli, Alberto
Publicado em 2008

Multi-Determinants Analysis of Molecular Alterations for Predicting Clinical Benefit to EGFR-Targeted Monoclonal Antibodies in Colorectal Cancer

Por Sartore-Bianchi, Andrea, Di Nicolantonio, Federica, Nichelatti, Michele, Molinari, Francesca, De Dosso, Sara, Saletti, Piercarlo, Martini, Miriam, Cipani, Tiziana, Marrapese, Giovanna, Mazzucchelli, Luca, Lamba, Simona, Veronese, Silvio, Frattini, Milo, Bardelli, Alberto, Siena, Salvatore
Publicado em 2009

Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers

Por Misale, Sandra, Bozic, Ivana, Tong, Jingshan, Peraza-Penton, Ashley, Lallo, Alice, Baldi, Federica, Lin, Kevin H., Truini, Mauro, Trusolino, Livio, Bertotti, Andrea, Di Nicolantonio, Federica, Nowak, Martin A., Zhang, Lin, Wood, Kris C., Bardelli, Alberto
Publicado no Nat Commun (2015)

Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus

Por Di Nicolantonio, Federica, Arena, Sabrina, Tabernero, Josep, Grosso, Stefano, Molinari, Francesca, Macarulla, Teresa, Russo, Mariangela, Cancelliere, Carlotta, Zecchin, Davide, Mazzucchelli, Luca, Sasazuki, Takehiko, Shirasawa, Senji, Geuna, Massimo, Frattini, Milo, Baselga, José, Gallicchio, Margherita, Biffo, Stefano, Bardelli, Alberto
Publicado em 2010

Cancer cell adaptation to chemotherapy

Por Di Nicolantonio, Federica, Mercer, Stuart J, Knight, Louise A, Gabriel, Francis G, Whitehouse, Pauline A, Sharma, Sanjay, Fernando, Augusta, Glaysher, Sharon, Di Palma, Silvana, Johnson, Penny, Somers, Shaw S, Toh, Simon, Higgins, Bernie, Lamont, Alan, Gulliford, Tim, Hurren, Jeremy, Yiangou, Constantinos, Cree, Ian A
Publicado em 2005

Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer

Por Van Emburgh, Beth O., Arena, Sabrina, Siravegna, Giulia, Lazzari, Luca, Crisafulli, Giovanni, Corti, Giorgio, Mussolin, Benedetta, Baldi, Federica, Buscarino, Michela, Bartolini, Alice, Valtorta, Emanuele, Vidal, Joana, Bellosillo, Beatriz, Germano, Giovanni, Pietrantonio, Filippo, Ponzetti, Agostino, Albanell, Joan, Siena, Salvatore, Sartore-Bianchi, Andrea, Di Nicolantonio, Federica, Montagut, Clara, Bardelli, Alberto
Publicado no Nat Commun (2016)

Emergence of KRAS mutations and acquired resistance to anti EGFR therapy in colorectal cancer

Por Misale, Sandra, Yaeger, Rona, Hobor, Sebastijan, Scala, Elisa, Janakiraman, Manickam, Liska, David, Valtorta, Emanuele, Schiavo, Roberta, Buscarino, Michela, Siravegna, Giulia, Bencardino, Katia, Cercek, Andrea, Chen, Chin-Tung, Veronese, Silvio, Zanon, Carlo, Sartore-Bianchi, Andrea, Gambacorta, Marcello, Gallicchio, Margherita, Vakiani, Efsevia, Boscaro, Valentina, Medico, Enzo, Weiser, Martin, Siena, Salvatore, Di Nicolantonio, Federica, Solit, David, Bardelli, Alberto
Publicado em 2012

Tumor heterogeneity and lesion-specific response to targeted therapy in colorectal cancer

Por Russo, Mariangela, Siravegna, Giulia, Blaszkowsky, Lawrence S., Corti, Giorgio, Crisafulli, Giovanni, Ahronian, Leanne G., Mussolin, Benedetta, Kwak, Eunice L., Buscarino, Michela, Lazzari, Luca, Valtorta, Emanuele, Truini, Mauro, Jessop, Nicholas A., Robinson, Hayley E., Hong, Theodore S., Mino-Kenudson, Mari, Di Nicolantonio, Federica, Thabet, Ashraf, Sartore-Bianchi, Andrea, Siena, Salvatore, Iafrate, A. John, Bardelli, Alberto, Corcoran, Ryan B.
Publicado no Cancer Discov (2015)

Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer

Por Bardelli, Alberto, Corso, Simona, Bertotti, Andrea, Hobor, Sebastijan, Valtorta, Emanuele, Siravegna, Giulia, Sartore-Bianchi, Andrea, Scala, Elisa, Cassingena, Andrea, Zecchin, Davide, Apicella, Maria, Migliardi, Giorgia, Galimi, Francesco, Lauricella, Calogero, Zanon, Carlo, Perera, Timothy, Veronese, Silvio, Corti, Giorgio, Amatu, Alessio, Gambacorta, Marcello, Diaz, Luis A., Sausen, Mark, Velculescu, Victor E., Comoglio, Paolo, Trusolino, Livio, Di Nicolantonio, Federica, Giordano, Silvia, Siena, Salvatore
Publicado em 2013

Monitoring clonal evolution and resistance to EGFR blockade in the blood of metastatic colorectal cancer patients

Por Siravegna, Giulia, Mussolin, Benedetta, Buscarino, Michela, Corti, Giorgio, Cassingena, Andrea, Crisafulli, Giovanni, Ponzetti, Agostino, Cremolini, Chiara, Amatu, Alessio, Lauricella, Calogero, Lamba, Simona, Hobor, Sebastijan, Avallone, Antonio, Valtorta, Emanuele, Rospo, Giuseppe, Medico, Enzo, Motta, Valentina, Antoniotti, Carlotta, Tatangelo, Fabiana, Bellosillo, Beatriz, Veronese, Silvio, Budillon, Alfredo, Montagut, Clara, Racca, Patrizia, Marsoni, Silvia, Falcone, Alfredo, Corcoran, Ryan B., Di Nicolantonio, Federica, Loupakis, Fotios, Siena, Salvatore, Sartore-Bianchi, Andrea, Bardelli, Alberto
Publicado no Nat Med (2015)

Molecular landscape of acquired resistance to targeted therapy combinations in BRAF mutant colorectal cancer

Por Oddo, Daniele, Sennott, Erin M., Barault, Ludovic, Valtorta, Emanuele, Arena, Sabrina, Cassingena, Andrea, Filiciotto, Genny, Marzolla, Giulia, Elez, Elena, van Geel, Robin M.J.M., Bartolini, Alice, Crisafulli, Giovanni, Boscaro, Valentina, Godfrey, Jason T., Buscarino, Michela, Cancelliere, Carlotta, Linnebacher, Michael, Corti, Giorgio, Truini, Mauro, Siravegna, Giulia, Grasselli, Julieta, Gallicchio, Margherita, Bernards, René, Schellens, Jan H.M., Tabernero, Josep, Engelman, Jeffrey A., Sartore-Bianchi, Andrea, Bardelli, Alberto, Siena, Salvatore, Corcoran, Ryan B., Di Nicolantonio, Federica
Publicado no Cancer Res (2016)