The in vitro effect of gefitinib ('Iressa') alone and in combination with cytotoxic chemotherapy on human solid tumours

BACKGROUND: Activation of the epidermal growth factor receptor (EGFR) triggers downstream signaling pathways that regulate many cellular processes involved in tumour survival and growth. Gefitinib ('Iressa') is an orally active tyrosine kinase inhibitor (TKI) targeted to the ATP-binding do...

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Detalhes bibliográficos
Main Authors: Knight, Louise A, Di Nicolantonio, Federica, Whitehouse, Pauline, Mercer, Stuart, Sharma, Sanjay, Glaysher, Sharon, Johnson, Penny, Cree, Ian A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2004
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC535559/
https://ncbi.nlm.nih.gov/pubmed/15560844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-4-83
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