Replacement of normal with mutant alleles in the genome of normal human cells unveils mutation-specific drug responses

Mutations in oncogenes and tumor suppressor genes are responsible for tumorigenesis and represent favored therapeutic targets in oncology. We exploited homologous recombination to knock-in individual cancer mutations in the genome of nontransformed human cells. Sequential introduction of multiple mu...

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Detalhes bibliográficos
Main Authors: Di Nicolantonio, Federica, Arena, Sabrina, Gallicchio, Margherita, Zecchin, Davide, Martini, Miriam, Flonta, Simona Emilia, Stella, Giulia Maria, Lamba, Simona, Cancelliere, Carlotta, Russo, Mariangela, Geuna, Massimo, Appendino, Giovanni, Fantozzi, Roberto, Medico, Enzo, Bardelli, Alberto
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2634925/
https://ncbi.nlm.nih.gov/pubmed/19106301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808757105
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